Radiobiological quantities in proton-therapy: Estimation and validation using Geant4-based Monte Carlo simulations
Language English Country Italy Media print-electronic
Document type Journal Article
PubMed
30824153
DOI
10.1016/j.ejmp.2019.01.018
PII: S1120-1797(19)30018-3
Knihovny.cz E-resources
- Keywords
- Geant4, Monte Carlo, Proton, RBE, Radiobiological model, Radiotherapy, Survival fraction,
- MeSH
- Radiotherapy Dosage MeSH
- Humans MeSH
- Monte Carlo Method * MeSH
- Cell Line, Tumor MeSH
- Proton Therapy * MeSH
- Radiobiology MeSH
- Reproducibility of Results MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
PURPOSE: The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams. METHODS: The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data. RESULTS AND CONCLUSIONS: The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines.
ELI Beamline Project Inst Physics ASCR PALS Center Prague Czech Republic
INFN TO Istituto Nazionale di Fisica Nucleare Sezione di Torino Torino Italy
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