Antidotes Against Methanol Poisoning: A Review
Language English Country Netherlands Media print
Document type Journal Article, Review
PubMed
30864518
DOI
10.2174/1389557519666190312150407
PII: MRMC-EPUB-97262
Knihovny.cz E-resources
- Keywords
- Alcohol dehydrogenase, aldehyde dehydrogenase, catalase, ethanol, folic acid, fomepizole, formaldehyde, formic acid, methanol, tetrahydrofolate, therapy.,
- MeSH
- Alcohol Dehydrogenase antagonists & inhibitors metabolism MeSH
- Antidotes chemistry pharmacology MeSH
- Enzyme Inhibitors chemistry pharmacology MeSH
- Humans MeSH
- Methanol antagonists & inhibitors poisoning MeSH
- Molecular Structure MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Alcohol Dehydrogenase MeSH
- Antidotes MeSH
- Enzyme Inhibitors MeSH
- Methanol MeSH
Methanol is the simplest alcohol. Compared to ethanol that is fully detoxified by metabolism. Methanol gets activated in toxic products by the enzymes, alcohol dehydrogenase and aldehyde dehydrogenase. Paradoxically, the same enzymes convert ethanol to harmless acetic acid. This review is focused on a discussion and overview of the literature devoted to methanol toxicology and antidotal therapy. Regarding the antidotal therapy, three main approaches are presented in the text: 1) ethanol as a competitive inhibitor in alcohol dehydrogenase; 2) use of drugs like fomepizole inhibiting alcohol dehydrogenase; 3) tetrahydrofolic acid and its analogues reacting with the formate as a final product of methanol metabolism. All the types of antidotal therapies are described and how they protect from toxic sequelae of methanol is explained.
References provided by Crossref.org
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