Method for determination of optical purity of 2-arylpropanoic acids using urea derivatives based on a 1,1'-binaphthalene skeleton as chiral NMR solvating agents: Advantages and limitations thereof
Status PubMed-not-MEDLINE Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
17-00089S
Czech Science Foundation - International
PubMed
30920055
DOI
10.1002/chir.23067
Knihovny.cz E-resources
- Keywords
- arylpropanoic acids, binaphthalene, chiral solvating agent, nonsteroidal anti-inflammatory drugs, urea,
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Five optically active urea derivatives (1-5) were used as NMR solvating agents for analysis of the optical purity of different 2-arylpropanoic acids commonly used as nonsteroidal anti-inflammatory drugs. These novel chiral solvating agents were more efficient at discriminating the respective enantiomers of targets than the chiral solvating agents known so far, without the need to add a base for achieving the signal splitting. The advantages and limits of the use of these novel chiral solvating agents were studied.
Department of Organic Chemistry University of Chemistry and Technology Prague Czech Republic
Institute of Chemical Process Fundamentals Czech Academy of Sciences Prague Czech Republic
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