Imatinib-induced changes in the expression profile of microRNA in the plasma and heart of mice-A comparison with doxorubicin
Jazyk angličtina Země Francie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
31004989
DOI
10.1016/j.biopha.2019.108883
PII: S0753-3322(19)30286-0
Knihovny.cz E-zdroje
- Klíčová slova
- Biomarker, Cardiotoxicity, Doxorubicin, Imatinib, MicroRNA,
- MeSH
- doxorubicin toxicita MeSH
- imatinib mesylát farmakologie MeSH
- mikro RNA krev genetika metabolismus MeSH
- myši MeSH
- regulace genové exprese účinky léků MeSH
- srdce účinky léků MeSH
- transkriptom účinky léků MeSH
- troponin T krev genetika metabolismus MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- doxorubicin MeSH
- imatinib mesylát MeSH
- mikro RNA MeSH
- troponin T MeSH
Cardiotoxicity is a serious adverse reaction to cancer chemotherapy and may lead to critical heart damage. Imatinib mesylate (IMB), a selective tyrosine kinase inhibitor, is sometimes accompanied by severe cardiovascular complications. To minimize risk, early biomarkers of such complications are of utmost importance. At the present time, microRNAs (miRNAs) are intensively studied as potential biomarkers of many pathological processes. Many miRNAs appear to be specific in some tissues, including the heart. In the present study we have explored the potential of specific miRNAs to be early markers of IMB-induced cardiotoxicity. Doxorubicin (DOX), an anthracycline with well-known cardiotoxicity, was used for comparison. NMRI mice were treated with IMB or DOX for nine days in doses corresponding to the highest recommended doses in oncological patients, following which plasmatic levels of miRNAs were analyzed in miRNA microarrays and selected cardio-specific miRNAs were quantified using qPCR. The plasmatic level of miR-1a, miR-133a, miR-133b, miR-339, miR-7058, miR-6236 and miR-6240 were the most different between the IMB-treated and control mice. Interestingly, most of the miRNAs affected by DOX were also affected by IMB showing the same trends. Concerning selected microRNAs in the hearts of individual mice, only miR-34a was significantly increased after DOX treatment, and only miR-205 was significantly decreased after IMB and DOX treatment. However, no changes in any miRNA expression correlated with the level of troponin T, a classical marker of heart injury.
Faculty of Medicine in Hradec Králové Charles University Šimkova 870 Hradec Králové Czech Republic
Faculty of Pharmacy Charles University Heyrovského 1203 Hradec Králové Czech Republic
Citace poskytuje Crossref.org
