Different acute effects of fructose and glucose administration on hepatic fat content
Language English Country United States Media print
Document type Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
PubMed
31136656
DOI
10.1093/ajcn/nqy386
PII: S0002-9165(22)03207-5
Knihovny.cz E-resources
- Keywords
- dietary fat, fructose, glucose, healthy volunteers, hepatic fat content, insulin, nonesterified fatty acids, proton magnetic resonance spectroscopy,
- MeSH
- Adult MeSH
- Fructose metabolism MeSH
- Glucose metabolism MeSH
- Insulin blood MeSH
- Liver metabolism MeSH
- Fatty Acids, Nonesterified blood MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Triglycerides blood MeSH
- Fats metabolism MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
- Names of Substances
- Fructose MeSH
- Glucose MeSH
- Insulin MeSH
- Fatty Acids, Nonesterified MeSH
- Triglycerides MeSH
- Fats MeSH
BACKGROUND: Diets rich in fat and added sugars (especially fructose) play an important role in the pathogenesis of nonalcoholic liver disease (NAFLD), but there is only limited information on the acute effects of these nutrients on hepatic fat content (HFC). OBJECTIVES: We therefore explored how the administration of high-fat load, glucose, fructose, and combinations thereof affects HFC measured in vivo using proton magnetic resonance spectroscopy (1H-MRS) in healthy subjects. METHODS: Ten healthy nonsteatotic male volunteers (age 38.5 ± 9.6 y, body mass index [BMI, kg/m2] 26.9 ± 2.7) underwent, in random order, 6 experiments, each lasting 8 h, that included: 1) fasting; 2) a high-fat load (150 g of fat [dairy cream] at time 0); 3) glucose (3 doses of 50 g at 0, 2, and 4 h); 4) a high-fat load with glucose; 5) fructose (3 doses of 50 g at 0, 2, and 4 h); and 6) a high-fat load with fructose. HFC was measured using 1H-MRS prior to test meal administration (before time 0) and at 3 and 6 h. Plasma concentrations of triglycerides, nonesterified fatty acids, glucose, and insulin were monitored throughout each experiment. RESULTS: HFC increased to 119 ± 19% (P < 0.05) and 117 ± 17% (P < 0.01) of baseline when subjects consumed a high-fat load alone or a high-fat load with fructose, respectively, but was not affected when glucose was coadministered with a high-fat load. HFC was not affected when subjects had fasted or had consumed repeated doses of fructose. When subjects were administered 3 doses of glucose, HFC dropped to 85 ± 13% (P < 0.05) of baseline. CONCLUSIONS: Our results demonstrate that fructose and glucose have a different immediate impact on HFC in humans in vivo. Clinical trial registry: The study was registered at clinicaltrials.gov and obtained clinicaltrials.gov identifier: NCT03680248.
Department of Physiology Faculty of Science Charles University Prague Czech Republic
Institute for Clinical and Experimental Medicine Prague Czech Republic
References provided by Crossref.org
Nutrient-Induced Changes of Liver Fat Content in Humans
ClinicalTrials.gov
NCT03680248
