Therapeutic potential of naringin in neurological disorders
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Review
PubMed
31252025
DOI
10.1016/j.fct.2019.110646
PII: S0278-6915(19)30435-1
Knihovny.cz E-resources
- Keywords
- Antineuroinflammation, Antioxidant, Naringin antiapoptotic, Neuroprotective, Polyphenols,
- MeSH
- Flavanones chemistry therapeutic use MeSH
- Humans MeSH
- Nervous System Diseases drug therapy MeSH
- Neuroprotective Agents chemistry therapeutic use MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Flavanones MeSH
- naringin MeSH Browser
- Neuroprotective Agents MeSH
Neurological illnesses are multifactorial incurable debilitating disorders that may cause neurodegeneration. These diseases influence approximately 30 million people around the world. Despite several therapies, effective management of such disorders remains a global challenge. Thus, natural products might offer an alternative therapy for the treatment of various neurological disorders. Polyphenols, such as curcumin, resveratrol, myricetin, mangiferin and naringin (NRG) have been shown to possess promising potential in the treatment of neurogenerative illness. In this review, we have targeted the therapeutic potential of naringin as a neuroprotective agent. The overall neuroprotective effects and different possible underlying mechanisms related to NRG are discussed. In light of the strong evidence for the neuropharmacological efficacy of NRG in various experimental paradigms, it is concluded that this molecule should be further considered and studied as a potential candidate for neurotherapeutics, focusing on mechanistic and clinical trials to ascertain its efficacy.
Department of Molecular Pharmacology Albert Einstein College of Medicine Bronx NY 10461 USA
Department of Pharmacy Abdul Wali Khan University Mardan 23200 Pakistan
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