Despite a significant transformation of ischaemic stroke management, it remains one of the leading causes of death, disability, functional impairment and cognitive deficits. With the advent of intravenous thrombolysis and mechanical thrombectomy, stroke is not an untreatable disease, mostly occurring in older people, any more. The most common cause of cardioembolic strokes is atrial fibrillation or flutter and atrial fibrillation is the most prevalent arrhythmia.The aim of this short communication is to describe the methodology of the Czech stroke guidelines development.High-quality 2017 Australian Stroke Foundation stroke guideline was considered for adaptation and a new guideline was developed and disseminated.

Czech National Centre for Evidence Based Healthcare and Knowledge Translation Institute of Biostatistics and Analyses Faculty of Medicine Masaryk University Brno

Department of Neurology Faculty of Medicine University Hospital Brno Masaryk University Brno

Department of Neurology Faculty of Medicine University Hospital Olomouc Palacky University Olomouc

Department of Neurology Faculty of Medicine University Hospital Ostrava Ostrava University Ostrava

Department of Neurology Regional Hospital Chomutov Chomutov

Department of Paediatrics T Bata Regional Hospital Zlin Czech Republic

Motol University Hospital Department of Neurology 2nd Faculty of Medicine Charles University Prague

Stroke Unit Peterborough City Hospital Peterborough UK

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Evaluation of blood-brain barrier integrity by the analysis of dynamic contrast-enhanced MRI - a comparison of quantitative and semi-quantitative methods