The rare stable isotope of hydrogen, deuterium, has fascinated researchers since its discovery in the 1930s. Subsequent large-scale production of deuterium oxide, commonly known as heavy water, became a starting point for further research. Deuterium exhibits unique physicochemical properties as well as having the strongest kinetic isotope effects among all other elements. Moreover, a broad variety of morphological and physiological changes have been observed in deuterium-treated cells and organisms, including changes in fundamental processes such as cell division or energy metabolism. Even though our understanding of such alterations is still insufficient, it is evident that some of them make growth in a deuterium-enriched environment a challenging task. There seems to be certain species-specific limits to their tolerance to heavy water, where some organisms are unable to grow in heavy water whilst others have no difficulties. Although the effects of deuterium on living organisms are, in general, negative, some of its applications are of great biotechnological potential, as is the case of stable isotope-labelled compounds or deuterated drugs.

Institute of Microbiology Centre Algatech Laboratory of Cell Cycles of Algae Opatovický Mlýn Czech Academy of Sciences 379 81 Třeboň Czech Republic

Zobrazit více v PubMed

J Chromatogr A. 2011 Dec 30;1218(52):9366-74 PubMed

Exp Cell Res. 1962 Feb;26:43-61 PubMed

Biotechnol Lett. 2006 Sep;28(17):1371-5 PubMed

Am J Physiol. 1961 Aug;201:357-62 PubMed

Ann N Y Acad Sci. 1960 Nov 25;84:763-9 PubMed

Clin Pharmacol Drug Dev. 2013 Jan;2(1):53-66 PubMed

Biol Bull. 1972 Dec;143(3):513-24 PubMed

Exp Ther Med. 2010 Mar;1(2):277-283 PubMed

Am J Clin Nutr. 1998 Sep;68(3):668-74 PubMed

Trends Ecol Evol. 2006 Jul;21(7):408-14 PubMed

Rapid Commun Mass Spectrom. 2018 Dec 30;32(24):2129-2140 PubMed

Anticancer Drugs. 1998 Sep;9(8):715-25 PubMed

J Neurosurg. 2002 May;96(5):900-8 PubMed

Biomol Eng. 2005 Dec;22(5-6):193-200 PubMed

FEBS Lett. 1993 Feb 8;317(1-2):1-4 PubMed

Expert Rev Vaccines. 2009 Nov;8(11):1587-602 PubMed

Carbohydr Res. 2012 May 15;353:57-61 PubMed

Biochim Biophys Acta. 1984 Jul 16;800(1):21-7 PubMed

Curr Opin Biotechnol. 2016 Oct;41:34-42 PubMed

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):E194-203 PubMed

J Clin Invest. 1967 Mar;46(3):313-22 PubMed

Life Sci. 1973 Oct 1;13(7):775-82 PubMed

Biotechnol Lett. 2013 Jul;35(7):1067-72 PubMed

J Cell Sci. 1991 Apr;98 ( Pt 4):463-73 PubMed

Proc Natl Acad Sci U S A. 1959 Apr;45(4):581-6 PubMed

Biochemistry. 1999 Mar 9;38(10):3067-72 PubMed

Science. 1933 Dec 22;78(2034):566-71 PubMed

Vaccine. 1995 Aug;13(12):1058-63 PubMed

Methods Mol Biol. 2011;753:29-42 PubMed

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E110-6 PubMed

J Pharmacol Exp Ther. 2015 Jul;354(1):43-54 PubMed

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1471-9 PubMed

Bull Tokyo Dent Coll. 2010;51(4):175-83 PubMed

J Pharmacol Exp Ther. 2017 Aug;362(2):359-367 PubMed

Br J Nutr. 2001 Apr;85(4):415-30 PubMed

Curr Opin Biotechnol. 2013 Feb;24(1):54-9 PubMed

Mass Spectrom Rev. 2017 Jan;36(1):58-85 PubMed

Exp Cell Res. 1968 Aug-Sep;51(2-3):602-8 PubMed

In Vivo. 2000 May-Jun;14(3):437-9 PubMed

Biochim Biophys Acta. 2008 Apr;1777(4):343-50 PubMed

Theor Biol Med Model. 2007 Feb 22;4:9 PubMed

Biotechnol Adv. 2018 May - Jun;36(3):784-797 PubMed

Science. 1966 Mar 11;151(3715):1187-94 PubMed

Proc Soc Exp Biol Med. 1960 Dec;105:481-3 PubMed

Virchows Arch A Pathol Anat Histol. 1979 Jul 31;383(2):149-66 PubMed

Biochemistry. 2000 May 2;39(17):5075-81 PubMed

Am J Clin Nutr. 1987 Jan;45(1):1-6 PubMed

Eur J Clin Nutr. 2000 May;54(5):386-94 PubMed

Plant Physiol. 1996 Oct;112(2):759-66 PubMed

FEBS Lett. 1990 May 21;264(2):203-5 PubMed

Ann N Y Acad Sci. 1960 Nov 25;84:648-66 PubMed

Biochim Biophys Acta. 1960 Jan 15;37:280-7 PubMed

Science. 1934 Feb 16;79(2042):151-3 PubMed

Ann N Y Acad Sci. 1960 Nov 25;84:770-9 PubMed

Biochim Biophys Acta. 1966 May 12;120(1):19-22 PubMed

J Med Chem. 2014 May 8;57(9):3595-611 PubMed

Science. 1960 Jan 1;131(3392):37-8 PubMed

Biochim Biophys Acta. 2011 Feb;1810(2):218-25 PubMed

Appl Environ Microbiol. 2005 May;71(5):2256-9 PubMed

Nucleic Acids Res. 2015 Feb 27;43(4):2466-85 PubMed

Biophys J. 2002 Jun;82(6):3246-53 PubMed

J Mass Spectrom. 2015 Jun;50(6):838-43 PubMed

J Pharm Sci. 1975 Mar;64(3):367-91 PubMed

Methods Enzymol. 1986;127:662-78 PubMed

Clin Pharmacol Ther. 1972 May-Jun;13(3):307-16 PubMed

J Proteomics. 2013 Aug 2;88:27-33 PubMed

Special issue dedicated to the memory of Ivan Šetlík