Harmonization of proton treatment planning for head and neck cancer using pencil beam scanning: first report of the IPACS collaboration group
Jazyk angličtina Země Švédsko Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie
- MeSH
- fotony terapeutické užití MeSH
- kochlea účinky záření MeSH
- kritické orgány * účinky záření MeSH
- larynx účinky záření MeSH
- lidé MeSH
- mezinárodní spolupráce * MeSH
- mozkový kmen účinky záření MeSH
- nádory hlavy a krku diagnostické zobrazování radioterapie MeSH
- nádory nosu diagnostické zobrazování radioterapie MeSH
- nádory vedlejších dutin nosních diagnostické zobrazování radioterapie MeSH
- nervus opticus účinky záření MeSH
- parotis účinky záření MeSH
- plánování radioterapie pomocí počítače metody MeSH
- počítačová rentgenová tomografie MeSH
- protonová terapie metody MeSH
- radioterapie s modulovanou intenzitou metody MeSH
- tumor burden MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Geografické názvy
- Evropa MeSH
Background and purpose: A collaborative network between proton therapy (PT) centres in Trento in Italy, Poland, Austria, Czech Republic and Sweden (IPACS) was founded to implement trials and harmonize PT. This is the first report of IPACS with the aim to show the level of harmonization that can be achieved for proton therapy planning of head and neck (sino-nasal) cancer.Methods: CT-data sets of five patients were included. During several face-to-face and online meetings, a common treatment planning protocol was developed. Each centre used its own treatment planning system (TPS) and planning approach with some restrictions specified in the treatment planning protocol. In addition, volumetric modulated arc therapy (VMAT) photon plans were created.Results: For CTV1, the average Dmedian was 59.3 ± 2.4 Gy(RBE) for protons and 58.8 ± 2.0 Gy(RBE) for VMAT (aim was 56 Gy(RBE)). For CTV2, the average Dmedian was 71.2 ± 1.0 Gy(RBE) for protons and 70.6 ± 0.4 Gy(RBE) for VMAT (aim was 70 Gy(RBE)). The average D2% for the spinal cord was 25.1 ± 8.5 Gy(RBE) for protons and 47.6 ± 1.4 Gy(RBE) for VMAT. The average D2% for chiasm was 46.5 ± 4.4 Gy(RBE) for protons and 50.8 ± 1.4 Gy(RBE) for VMAT, respectively. Robust evaluation was performed and showed the least robust plans for plans with a low number of beams.Discussion: In conclusion, several influences on harmonization were identified: adherence/interpretation to/of the protocol, available technology, experience in treatment planning and use of different beam arrangements. In future, all OARs that should be included in the optimization need to be specified in order to further harmonize treatment planning.
Danish Centre for Particle Therapy Aarhus Denmark
Department of Radiation Physics University of Gothenburg Göteborg Sweden
Department of Therapeutic Radiation Physics Sahlgrenska University Hospital Göteborg Sweden
Institute of Nuclear Physics Polish Academy of Sciences Cyclotron Centre Bronowice Kraków Poland
MedAustron Ion Therapy Centre Wiener Neustadt Austria
Proton Therapy Centre Czech Medical Physics Prague Czechia
Proton Therapy Centre Czech Radiation Oncology Prague Czechia
Regional Cancer Center West Göteborg Sweden
The Skandion Clinic Uppsala Sweden
U O di Protonterapia Azienda Provinciale per 1 Servizi Sanitari Trento Trento Italy
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