Reactive modifications of DNA nucleobases for labelling, bioconjugations, and cross-linking
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
31415984
DOI
10.1016/j.cbpa.2019.07.007
PII: S1367-5931(19)30067-5
Knihovny.cz E-resources
- MeSH
- Alkylation MeSH
- Cycloaddition Reaction MeSH
- DNA chemistry MeSH
- Cross-Linking Reagents chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- DNA MeSH
- Cross-Linking Reagents MeSH
Modification of DNA with reactive groups and their post-synthetic transformations are useful for labelling, imaging, bioconjugations and cross-linking with other (bio)molecules. This review summarizes the recent progress in this field and covers transformations of oxo groups, cycloadditions, conjugate additions, alkylations, cross-couplings and other reactions. Examples of applications are given and the practicability and scope of the reactions are discussed.
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