Determination of nucleobase-pairing free energies from rotamer equilibria of 2-(methylamino)pyrimidines
Status PubMed-not-MEDLINE Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
31455961
DOI
10.1039/c9cc05513d
Knihovny.cz E-resources
- Publication type
- Journal Article MeSH
A fast straightforward method for the determination of free energies of modified nucleobase pairing is proposed. The method is based on the nuclear magnetic resonance (NMR) spectroscopy monitoring of conformational changes of 2-(methylamino)-pyrimidines upon intermolecular binding.
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