Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively-parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.

Althea Science Inc 3 Regent St 301 Livingston NJ 07039 USA

Barcelona Stem Cell Bank Centre of Regenerative Medicine in Barcelona Hospital Duran i Reynals Gran Via de l' Hospitalet 199 08908 Hospitalet de Llobregat Barcelona Spain

Bioethics Institute Ghent Department of Philosophy and Moral Science Ghent University Belgium

Centre for Medical Genetics UZ Brussel Laarbeeklaan 101 B 1090 Brussels Belgium

Department Genetics and Cell Biology GROW School for Oncology and Developmental Biology Maastricht University Medical Center P O Box 616 6200 MD Maastricht The Netherlands

Department of Biology and Medical Genetics Charles University 2nd Faculty of Medicine and Motol University Hospital 5 Úvalu 84 Prague CZ 15006 Czech Republic

Department of Clinical Genetics Amsterdam Public Health Research Institute VU University Medical Center PO Box 7057 1007 MB Amsterdam The Netherlands

Department of Health Ethics and Society Research Schools CAPHRI and GROW Maastricht University De Byeplein 1 6229 HA Maastricht The Netherlands

Department of Human Genetics KU Leuven O and N 1 Herestraat 49 Box 602 B 3000 Leuven Belgium

Department of Public Health and Primary Care Centre for Biomedical Ethics and Law KU Leuven Kapucijnenvoer 35 Box 7001 B 3000 Leuven Belgium

Helsinki Biobank Helsinki University Central Hospital Haartmaninkatu 3 PO Box 400 00029 HUS Helsinki Finland

Institute for Women's Health University College London 86 96 Chenies Mews London WC1E 6HX UK

Institute of Parasitology and Pathology University of Strasbourg 3 rue Koberlé 67000 Strasbourg France

IVF laboratory Department of Obstetrics and Gynaecology Maastricht University Medical Center PO Box 5800 6202 AZ Maastricht The Netherlands

Laboratory of Genetic Diagnostics UF3472 Genetics of Infertility Nouvel Hôpital Civil 1 place de l'Hôpital 67091 Strasbourg cedex France

Laboratory of Genetics Helsinki University Hospital PO Box 720 FI 00029 Helsinki Finland

Reproductive Medicine Sahlgrenska University Hospital Blå Stråket 6 413 45 Göteborg Sweden

Reproductive Medicine Service of Dexeus Woman Health Gran Via Carles 3 71 75 08028 Barcelona Spain

Research Group Reproduction and Genetics Vrije Universiteit Brussel Laarbeeklaan 101 B 1090 Brussels Belgium

S 1 S Me R Reproductive Medicine Unit Via Mazzini 12 40138 Bologna Italy

Synlab Genetics chemin d'Entre Bois 21 CH 1018 Lausanne Switzerland

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