Easy and Inexpensive Method for Multiclass Analysis of 41 Food Contact Related Contaminants in Fatty Food by Liquid Chromatography-Tandem Mass Spectrometry
Language English Country United States Media print-electronic
Document type Evaluation Study, Journal Article
- Keywords
- endocrine disruptors, fatty food, food contact materials, liquid chromatography−mass spectrometry, liquid−liquid extraction, methanol-associated sensitivity loss,
- MeSH
- Food Analysis methods MeSH
- Benzhydryl Compounds analysis MeSH
- Phenols analysis MeSH
- Food Contamination analysis MeSH
- Phthalic Acids analysis MeSH
- Tandem Mass Spectrometry methods MeSH
- Chromatography, High Pressure Liquid methods MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Names of Substances
- Benzhydryl Compounds MeSH
- bisphenol A MeSH Browser
- Phenols MeSH
- Phthalic Acids MeSH
- phthalic acid MeSH Browser
Food contact materials (FCMs) may release their chemical components into food and thus raise safety concerns. This paper attempted to study the presence of four major groups of FCM-related endocrine disruptors in fatty food: dialkyl phthalates, bisphenols, printing ink photoinitiators, and polyfluoroalkyl substances. All 41 target compounds were analyzed simultaneously by means of liquid chromatography coupled to tandem mass spectrometry. The sample preparation was significantly streamlined to reduce analysis costs by employing acetonitrile extraction, extract modification by water, and refrigeration at 5 °C. The new method was validated and applied to 60 real samples, including edible oils, butter, and chocolate, where 16 target compounds were measured at levels ≤13000 ng/g. The study also described the blank level increase and sensitivity loss caused by impurities present in the HPLC methanol solvent.
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