Immunophenotyping of Paroxysmal Nocturnal Hemoglobinuria (PNH)
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
- Klíčová slova
- Aplastic anemia (AA), CD59, FLAER, Glycophosphatidylinositol (GPI)-anchored protein, Myelodysplastic syndrome (MDS), Paroxysmal nocturnal hemoglobinuria (PNH),
- MeSH
- antigeny CD59 imunologie MeSH
- erytrocyty imunologie MeSH
- imunofenotypizace metody MeSH
- leukocyty imunologie MeSH
- lidé MeSH
- paroxysmální hemoglobinurie krev imunologie MeSH
- průtoková cytometrie metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigeny CD59 MeSH
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare but often debilitating disease which may lead to death in up to 35% of patients within 5 years if unrecognized and untreated. Detection of PNH and assessment of PNH clone size in RBC and WBC lineages by flow cytometric analysis has increased in importance due to the availability of novel therapies. These therapies typically block the hemolysis of red blood cells and thus significantly lower the morbidities and mortality associated with this disease. This chapter describes validated, state-of-the-art, high-sensitivity flow cytometric methodologies based on latest published testing guidelines for PNH.
Dahl Chase Diagnostic Services Bangor ME USA
Institute of Hematology and Blood Transfusion Prague 2 Czech Republic
Citace poskytuje Crossref.org
