Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to radiation therapy limit their immunogenicity as a consequence of reduced type I interferon secretion. Thus, caspase inhibitors stand out as promising combinatorial partners to improve the immunogenicity of radiation therapy in the clinic.

Department of Dermatology Yale School of Medicine New Haven CT USA

Department of Immunology Charles University Faculty of Medicine and University Hospital Motol Prague Czech Republic

Department of Radiation Oncology University of Navarra Clinic and CIMA Pamplona Spain

Department of Radiation Oncology Weill Cornell Medical College New York NY USA

Sandra and Edward Meyer Cancer Center New York NY USA

Sotio Prague Czech Republic

Université Paris Descartes Paris 5 Paris France

Zobrazit více v PubMed

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Calreticulin and cancer

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology