Anti-MRSA activity of abietane diterpenes from Coleus blumei Benth
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
- Keywords
- Coleus blumei, column chromatography, diterpenoids anti-MRSA activity,
- MeSH
- Coleus * chemistry MeSH
- Abietanes isolation & purification pharmacology MeSH
- Diterpenes * isolation & purification pharmacology MeSH
- Phytochemicals isolation & purification pharmacology MeSH
- Methicillin-Resistant Staphylococcus aureus * drug effects MeSH
- Staphylococcus drug effects MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Abietanes MeSH
- Diterpenes * MeSH
- Phytochemicals MeSH
Two heretofore uncharacterised abietane diterpenes, sincoetsin C (1) and 3-hydroxyspirocoleon 7-O-β-D-glucoside (4), were isolated from a methanolic extract of Coleus blumei Benth. (Lamiaceae), along with the known compounds, scutellarioidone A (2) and spirocoleon 7-O-β-D-glucoside (3) using chromatographic techniques. Their structures were determined by 1D and 2D nuclear magnetic resonance including HSQC, HMBC, COSY and NOESY experiments, mass spectrometry (HR-MS) and other spectroscopic methods (UV, IR). Their antibacterial activity against the reference strain of methicillin-resistant Staphylococcus aureus subsp. aureus CCM 4750 (MRSA) was evaluated using optical absorption to obtain quantitative information on their growth. All isolated compounds displayed anti-MRSA 4750 activity at the concentration of 512 μg/mL. Sincoetsin C (1) was the abietane diterpene most active against MRSA 4750, with a minimum inhibitory concentration of 128 μg/mL.
References provided by Crossref.org
Abietane Diterpenes of the Genus Plectranthus sensu lato
