Heterocycles in Medicinal Chemistry
Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu úvodníky
PubMed
31731387
PubMed Central
PMC6864827
DOI
10.3390/molecules24213839
PII: molecules24213839
Knihovny.cz E-zdroje
- MeSH
- chemie farmaceutická trendy MeSH
- heterocyklické sloučeniny chemie terapeutické užití MeSH
- lidé MeSH
- uhlík chemie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- úvodníky MeSH
- Názvy látek
- heterocyklické sloučeniny MeSH
- uhlík MeSH
Heteroatoms constitute a very common fragment of a number of active pharmaceutical ingredients as well as excipients; from the point of view of significance, it is all the same if these are isosterically/bioisosterically replaced carbons/carbon substructures in aliphatic structures or real heterocycles [...].
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Soler-Bistue A., Zorreguieta A., Tolmasky M.E. Bridged nucleic acids reloaded. Molecules. 2019;24:2297. doi: 10.3390/molecules24122297. PubMed DOI PMC
Pajak W., Fabijanska M., Wojciechowski J., Wolf W.M., Kilanowicz A., Brzezinska E., Ochocki J. Fluorimetric properties of 3-aminoflavone biomolecule (3-AF). X-ray crystal structure of new polymorph of 3-AF. Molecules. 2019;24:2927. doi: 10.3390/molecules24162927. PubMed DOI PMC
Cejka J., Cvak L., Zizkova S., Kratochvil B., Jegorov A. Dihydrogen bond in the aminoborane complex of a nicergoline intermediate. Molecules. 2019;24:2548. doi: 10.3390/molecules24142548. PubMed DOI PMC
Sulekova M., Vahovska L., Hudak A., Zid L., Zelenak V. A Study of 5-fluorouracil desorption from mesoporous silica by RP-UHPLC. Molecules. 2019;24:1317. doi: 10.3390/molecules24071317. PubMed DOI PMC
Pokorna A., Bobal P., Oravec M., Rarova L., Bobalova J., Jampilek J. Investigation of permeation of theophylline through skin using selected piperazine-2,5-diones. Molecules. 2019;24:566. doi: 10.3390/molecules24030566. PubMed DOI PMC
Awad S.M., Zohny Y.M., Ali S.A., Mahgoub S., Said A.M. Design, synthesis, molecular modeling, and biological evaluation of novel thiouracil derivatives as potential antithyroid agents. Molecules. 2018;23:2913. doi: 10.3390/molecules23112913. PubMed DOI PMC
Pardo-Jiménez V., Navarrete-Encina P., Diaz-Araya G. Synthesis and biological evaluation of novel thiazolyl-coumarin derivatives as potent histone deacetylase inhibitors with antifibrotic activity. Molecules. 2019;24:739. doi: 10.3390/molecules24040739. PubMed DOI PMC
Osmaniye D., Saglik B.N., Acar Cevik U., Levent S., Kaya Cavusoglu B., Ozkay Y., Kaplancikli Z.A., Turan G. Synthesis and AChE inhibitory activity of novel thiazolylhydrazone derivatives. Molecules. 2019;24:2392. doi: 10.3390/molecules24132392. PubMed DOI PMC
Lee M.H., Lapidus R.G., Ferraris D., Emadi A. Analysis of the mechanisms of action of naphthoquinone-based anti-acute myeloid leukemia chemotherapeutics. Molecules. 2019;24:3121. doi: 10.3390/molecules24173121. PubMed DOI PMC
Kubickova J., Elefantova K., Pavlikova L., Cagala M., Seres M., Safar P., Marchalin S., Durisova K., Bohacova V., Sulova Z., et al. Screening of phenanthroquinolizidine alkaloid derivatives for inducing cell death of L1210 leukemia cells with negative and positive P-glycoprotein expression. Molecules. 2019;24:2127. doi: 10.3390/molecules24112127. PubMed DOI PMC
Wang W., Lei L., Liu Z., Wang H., Meng Q. Design, synthesis, and biological evaluation of novel nitrogen heterocycle-containing ursolic acid analogs as antitumor agents. Molecules. 2019;24:877. doi: 10.3390/molecules24050877. PubMed DOI PMC
Ibric A., Eckerstorfer S., Eder M., Louko I., Tunjic L., Heffeter P., Schueffl H.H., Marian B., Haider N. Position-selective synthesis and biological evaluation of four isomeric A-ring amino derivatives of the alkaloid luotonin A. Molecules. 2019;24:716. doi: 10.3390/molecules24040716. PubMed DOI PMC
Bosco B., Defant A., Messina A., Incitti T., Sighel D., Bozza A., Ciribilli Y., Inga A., Casarosa S., Mancini I. Synthesis of 2,6-diamino-substituted purine derivatives and evaluation of cell cycle arrest in breast and colorectal cancer cells. Molecules. 2018;23:1996. doi: 10.3390/molecules23081996. PubMed DOI PMC
Abu-Hashem A.A. Synthesis of new furothiazolo pyrimido quinazolinones from visnagenone or khellinone and antimicrobial activity. Molecules. 2018;23:2793. doi: 10.3390/molecules23112793. PubMed DOI PMC
Malik I., Csollei J., Solovic I., Pospisilova S., Michnova H., Jampilek J., Cizek A., Kapustikova I., Curillova J., Pechacova M., et al. Dibasic derivatives of phenylcarbamic acid against mycobacterial strains: Old drugs and new tricks? Molecules. 2018;23:2493. doi: 10.3390/molecules23102493. PubMed DOI PMC
Bettencourt A., Castro M., Silva J., Fernandes F., Coutinho O., Sousa M.J., Proenca M.F., Areias F. New nitrogen compounds coupled to phenolic units with antioxidant and antifungal activities: Synthesis and structure-activity relationship. Molecules. 2018;23:2530. doi: 10.3390/molecules23102530. PubMed DOI PMC
Espinosa-Valdes M.P., Borbolla-Alvarez S., Delgado-Espinosa A.E., Sanchez-Tejeda J.F., Ceron-Nava A., Quintana-Romero O.J., Ariza-Castolo A., Garcia-Del Rio D.F., Loza-Mejia M.A. Synthesis, in silico, and in vitro evaluation of long chain alkyl amides from 2-amino-4-quinolone derivatives as biofilm inhibitors. Molecules. 2019;24:327. doi: 10.3390/molecules24020327. PubMed DOI PMC
Lasak P., Motyka K., Krystof V., Styskala J. Synthesis, bacteriostatic and anticancer activity of novel phenanthridines structurally similar to benzo[c]phenanthridine alkaloids. Molecules. 2018;23:2155. doi: 10.3390/molecules23092155. PubMed DOI PMC