Epidural analgesia with sufentanil in relation to OPRM1 and ABCB1 polymorphisms
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
31755291
DOI
10.33549/physiolres.934325
PII: 934325
Knihovny.cz E-resources
- MeSH
- Analgesia, Epidural methods MeSH
- Colorectal Neoplasms surgery MeSH
- Middle Aged MeSH
- Humans MeSH
- Pain Management methods MeSH
- Analgesics, Opioid administration & dosage MeSH
- ATP Binding Cassette Transporter, Subfamily B genetics MeSH
- Polymorphism, Genetic physiology MeSH
- Pain, Postoperative drug therapy MeSH
- Prospective Studies MeSH
- Receptors, Opioid, mu genetics MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Sufentanil administration & dosage MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- ABCB1 protein, human MeSH Browser
- Analgesics, Opioid MeSH
- OPRM1 protein, human MeSH Browser
- ATP Binding Cassette Transporter, Subfamily B MeSH
- Receptors, Opioid, mu MeSH
- Sufentanil MeSH
The aim of this study was to evaluate the association between OPRM1 and ABCB1 polymorphisms on pain relief with epidural sufentanil in 69 patients after rectosigma resection for cancer. The median number of injections (SD) 2.31 (1.36), IQR=1, required by 118AA subjects was significantly lower in comparison with 118AG group 5.25 (3.13), IQR=6.5, (chi(2)=9.75, p=0.001); correspondingly median drug consumption of 1.16 (0.79), IQR=1.083, defined daily doses (DDD) was significantly less in the 118AA group in comparison with 2.14 (1.17), IQR=2.23, DDD in 118AG subjects, (chi(2)=7.00, p=0.008). Opioid-induced adverse effects were observed in 15 % and 33 % of patients in 118AA and 118AG groups, respectively (chi(2)=8.16, p=0.004). The median number of injections (SD) required by women and men was 3.30 (2.16), IQR=2, and 2.80 (1.59), IQR=1, respectively (chi(2)=6.25, p=0.012). Opioid-induced adverse effects were observed in 26 % and 12 % of women and men, respectively (chi(2)=5.49, p=0.011). Heterozygotes of OPRM1 polymorphism and women were more difficult to treat subpopulations that required higher doses of rescue analgesic medication and suffered more adverse effects.
References provided by Crossref.org