The use of clays for chlorhexidine controlled release as a new perspective for longer durability of dentin adhesion
Jazyk angličtina Země Spojené státy americké Médium electronic
Typ dokumentu časopisecké články
PubMed
31786679
DOI
10.1007/s10856-019-6344-5
PII: 10.1007/s10856-019-6344-5
Knihovny.cz E-zdroje
- MeSH
- biokompatibilní materiály MeSH
- časové faktory MeSH
- chlorhexidin chemie MeSH
- dentin chemie MeSH
- dentinová adheziva MeSH
- jíl chemie MeSH
- léky s prodlouženým účinkem MeSH
- pevnost v tahu MeSH
- testování materiálů MeSH
- uvolňování léčiv * MeSH
- zubní materiály * MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- biokompatibilní materiály MeSH
- chlorhexidin MeSH
- dentinová adheziva MeSH
- jíl MeSH
- léky s prodlouženým účinkem MeSH
- zubní materiály * MeSH
The adhesive systems have the function to establish the connection between the restorative material and dental tissue, therefore it is of fundamental importance, because failures in the adhesive interface can reduce the life of a dental restoration. This study investigated the possibility of using the adhesive layer as a chlorhexidine modified release system evaluating their impact on the properties of these systems as well as evaluating the impact of these systems on immediate and post-aging dentin adhesion. Were used a matrix with BisGMA, UDMA, HEMA and TEGDMA copolymer and clay particles (Dellite 67G); associated with a chlorhexidine and a camphorquinone photoinitiator system. The properties of these systems were evaluated by the XRD, FTIR spectrophotometer, flexural strength, elasticity modulus, drug release, enzymatic inhibition and dentin adhesion resistance. The presence of the clay can raise the mechanical properties of the adhesive systems engendering a more resistant hybrid layer and led to a more sustained release of chlorhexidine in the systems, allowing a longer effective period of MMP-2 inhibition. The hypothesis that the addition of clays as release modulators could increase the effectiveness of these drugs in inhibiting the dentin's MPPs and consequently enhancing the adhesive durability was confirmed. These results indicate that the controlled release of chlorhexidine is able to reduce the process of loss of adhesion presenting itself as a promising system to increase the longevity of dental restorations.
Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas UNICAMP Campinas Brazil
Institute of Macromolecular Chemistry AS CR Prague Czech Republic
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