COMPARISON OF THE RADIATION SENSITIVITY OF THE BREAST CANCER CELL LINE MCF7 AND HUMAN ADIPOSE-DERIVED STEM CELLS
Language English Country Great Britain, England Media print
Document type Comparative Study, Journal Article
PubMed
31803908
DOI
10.1093/rpd/ncz193
PII: 5658466
Knihovny.cz E-resources
- MeSH
- Apoptosis radiation effects MeSH
- Stem Cells radiation effects MeSH
- Humans MeSH
- MCF-7 Cells radiation effects MeSH
- Cell Proliferation radiation effects MeSH
- Radiation Tolerance * MeSH
- Adipocytes radiation effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
A comparison between breast cancer cell line MCF7 and human adipose-derived stem cells (ADSC) after irradiation by the same doses of megavoltage X-rays was performed. The cell growth, the induction of apoptosis and the expression of selected genes were analyzed. Irradiated MCF7 related to its control sample grows slower than ADSC and it undergoes apoptosis in much higher levels than ADSC. This was confirmed by real-time polymerase chain reaction as well, where the expression of apoptotic genes was found to be considerably higher for MCF7 than for ADSC. From the results of this project, it could be stated that MCF7 is more radiosensitive than ADSC.
Institute of Physiology of the Czech Academy of Sciences Vídeňská 1083 14220 Prague Czech Republic
Institute of Radiation Oncology of the Hospital Na Bulovce Budínova 67 2 18081 Prague Czech Republic
Nuclear Physics Institute of the Czech Academy of Sciences Řež 130 25068 Řež Czech Republic
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