Collagen (CO)/chitosan-glucan complex (CSGC) hollow fibers encapsulated aloe vera (AV) dressing scaffold (CO/CSGC@AV) were fabricated for the first time by the freeze-dried process. Extraction process, morphology, mechanical properties, pore size, porosity, swelling ability, and degradation behavior of composites scaffold were investigated. CSGC hollow fibers were extracted from mycelium of Schizophyllum commune CSGC hollow fiber exhibited inner diameter of (600 ± 250 nm) and outer fiber diameter of (2.5 ± 0.5 μm). The results of swelling and hydrolytic degradation studies demonstrated that the physicochemical of CO/CSGC@AV was significantly enhanced by CSGC in a concentration-dependent manner. The mechanical property of the CO/CSGC@AV was improved after encapsulated AV into CSGC hollow fibers compared with native CO. The pore size and porosity of the CO/CSGC@AV were slightly decreased in the presence of AV. All these results suggested that the new dressing scaffold has a potential for clinical skin regeneration, particularly for infected chronic wounds and ulcers.

CEITEC Central European Institute of Technology Brno University of Technology Purkyňova 656 123 Brno 612 00 Czechia

CEITEC Central European Institute of Technology Brno University of Technology Purkyňova 656 123 Brno 612 00 Czechia; SCITEG a s Brno Czechia; Department of Pretreatment and Finishing of Cellulosic based Textiles Textile Industries Research Division National Research Centre 33 EL Buhouth St Dokki Giza 12622 Egypt

CEITEC Central European Institute of Technology Brno University of Technology Purkyňova 656 123 Brno 612 00 Czechia; SCITEG a s Brno Czechia; Institute of Materials Chemistry Faculty of Chemistry Brno University of Technology Purkyňova 464 118 Brno 612 00 Czechia

Institute of Macromolecular Chemistry of the Czech Academy of Sciences HeyRovskeho Nam 2 162 06 Prague 6 Czechia

Institute of Materials Chemistry Faculty of Chemistry Brno University of Technology Purkyňova 464 118 Brno 612 00 Czechia

Institute of Physics of Materials Academy of Sciences of the Czechia Žižkova 22 CZ 61662 Brno Czechia

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