In tick-borne encephalitis (TBE)-endemic regions, long-term vaccination programs are efficient in preventing the disease. A booster dose of a polygeline-free inactivated TBE vaccine (Encepur Adults, GSK), administered approximately 3 years post-primary vaccination according to 1 of 3 licensed vaccination schedules in adults and adolescents, resulted in antibody persistence for 10 years post-boosting. We used different power-law models (PLMs) to predict long-term persistence of anti-TBE virus neutralization test (NT) antibody titers over a period of 20 years post-booster dose, based on individual antibody NT titers measured for 10 years post-booster vaccination. The PLMs were fitted on pooled data for all vaccine schedules. A mean NT titer of 261 (95% prediction interval: 22-3096), considerably above the accepted threshold of protection (NT titers ≥10), was predicted 20 years post-booster vaccination with TBE vaccine. Our modeled data suggest that the intervals of booster doses could be increased without compromising protection against TBE.

Department for Tropical Travel Medicine and Immunization Institute for Postgraduate Medical Education Prague Prague 10 Czechia

GSK Rixensart Belgium

GSK Siena Italy

GSK Wavre Belgium

Vaccination and Travel Medicine Centre Hradec Králové Czechia

Hum Vaccin Immunother. 2020 Sep 1;16(9):2280-2281. doi: 10.1080/21645515.2020.1783954. PubMed

Hum Vaccin Immunother. 2020 Sep 1;16(9):2282-2284. doi: 10.1080/21645515.2020.1798713. PubMed

Zobrazit více v PubMed

European Centre for Disease Prevention and Control . Tick-borne encephalitis. ECDC. Annual Epidemiological Report for 2015. Stockholm: ECDC; 2018. [accessed 2019 August19]. http://ecdc.europa.eu/sites/portal/files/documents/AER_for_2015-tick-borne-encephalitis.pdf.

Kunze U; The ISW-TBE . Report of the 19th annual meeting of the International Scientific Working Group on Tick-Borne Encephalitis (ISW-TBE) - TBE in a changing world. Ticks Tick Borne Dis. 2018;9(2):146–50. doi:10.1016/j.ttbdis.2017.08.009. PubMed DOI

Lindquist L. Tick-borne encephalitis. Handb Clin Neurol. 2014;123:531–59. doi:10.1016/b978-0-444-53488-0.00025-0. PubMed DOI

Vaccines against tick-borne encephalitis: WHO position paper. Wkly Epidemiol Rec. 2011;86(24):241–56. PubMed

Kollaritsch H, Krasilnikov V, Holzmann H, Karganova G, Barrett A, Süss J.; World Health Organization (WHO) . Background document on vaccines and vaccination against tick–borne encephalitis. Geneva (Switzerland): WHO Strategic Advisory Group of Experts on Immunization; 2011. [accessed 2019 August19]. http://www.who.int/immunization/sage/6_TBE_backgr_18_Mar_net_apr_2011.pdf.

Galgani I, Bunge EM, Hendriks L, Schludermann C, Marano C, De Moerlooze L.. Systematic literature review comparing rapid 3-dose administration of the GSK tick-borne encephalitis vaccine with other primary immunization schedules. Expert Rev Vaccines. 2017;16(9):919–32. doi:10.1080/14760584.2017.1358620. PubMed DOI

Beran J, Douda P, Gniel D, Zent O. Long-term immunity after vaccination against tick-borne encephalitis with Encepur using the rapid vaccination schedule. Int J Med Microbiol. 2004;293(Suppl 37):130–33. doi:10.1016/S1433-1128(04)80023-8. PubMed DOI

Beran J, Lattanzi M, Xie F, Moraschini L, Galgani I. Second five-year follow-up after a booster vaccination against tick-borne encephalitis following different primary vaccination schedules demonstrates at least 10 years antibody persistence. Vaccine. 2019;37(32):4623–29. doi:10.1016/j.vaccine.2017.12.081. PubMed DOI

Leonova GN, Pavlenko EV. Characterization of neutralizing antibodies to far eastern of tick-borne encephalitis virus subtype and the antibody avidity for four tick-borne encephalitis vaccines in human. Vaccine. 2009;27(21):2899–904. doi:10.1016/j.vaccine.2009.02.069. PubMed DOI

Paulke-Korinek M, Rendi-Wagner P, Kundi M, Laaber B, Wiedermann U, Kollaritsch H. Booster vaccinations against tick-borne encephalitis: 6 years follow-up indicates long-term protection. Vaccine. 2009;27(50):7027–30. doi:10.1016/j.vaccine.2009.09.068. PubMed DOI

Schöndorf I, Beran J, Cizkova D, Lesna V, Banzhoff A, Zent O. Tick-borne encephalitis (TBE) vaccination: applying the most suitable vaccination schedule. Vaccine. 2007;25(8):1470–75. doi:10.1016/j.vaccine.2006.10.028. PubMed DOI

European Centre for Disease Prevention and Control . Vaccine scheduler. Tick-Borne Encephalitis: Recommended Vaccinations; [accessed 2019 August19]. http://vaccine-schedule.ecdc.europa.eu/Scheduler/ByDisease?SelectedDiseaseId=27&SelectedCountryIdByDisease=−1.

Konior R, Brzostek J, Pöllabauer EM, Jiang Q, Harper L, Erber W. Seropersistence of TBE virus antibodies 10 years after first booster vaccination and response to a second booster vaccination with FSME-IMMUN 0.5mL in adults. Vaccine. 2017. doi:10.1016/j.vaccine.2017.03.059. PubMed DOI

Klockmann U, Bock HL, Kwasny H, Praus M, Cihlová V, Tomková E, Křivanec K. Humoral immunity against tick-borne encephalitis virus following manifest disease and active immunization. Vaccine. 1991;9(1):42–46. doi:10.1016/0264-410X(91)90315-W. PubMed DOI

David MP, Van Herck K, Hardt K, Tibaldi F, Dubin G, Descamps D, Van Damme P. Long-term persistence of anti-HPV-16 and -18 antibodies induced by vaccination with the AS04-adjuvanted cervical cancer vaccine: modeling of sustained antibody responses. Gynecol Oncol. 2009;115(3 Suppl):S1–6. doi:10.1016/j.ygyno.2009.01.011. PubMed DOI

Fraser C, Tomassini JE, Xi L, Golm G, Watson M, Giuliano AR, Barr E, Ault KA. Modeling the long-term antibody response of a human papillomavirus (HPV) virus-like particle (VLP) type 16 prophylactic vaccine. Vaccine. 2007;25(21):4324–33. doi:10.1016/j.vaccine.2007.02.069. PubMed DOI

Holzmann H, Kundi M, Stiasny K, Clement J, McKenna P, Kunz C, Heinz FX. Correlation between ELISA, hemagglutination inhibition, and neutralization tests after vaccination against tick-borne encephalitis. J Med Virol. 1996;48(1):102–07. doi:10.1002/(sici)1096-9071(199601)48:1<102::aid-jmv16>3.0.co;2-i. PubMed DOI

Response letter: "Predicted long-term antibody persistence for a tick-borne encephalitis vaccine: results from a modeling study beyond 10 years after a booster dose following different primary vaccination schedules"