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Formal Transition-Metal-Catalyzed Phosphole C-H Activation for the Synthesis of Pentasubstituted Phospholes

. 2020 Mar 20 ; 22 (6) : 2187-2190. [epub] 20200303

Status PubMed-not-MEDLINE Language English Country United States Media print-electronic

Document type Journal Article

Unprecedented formal transition-metal-catalyzed phosphole C-H functionalization is described in this paper. Pentasubstituted phospholes were prepared via the copper-catalyzed reaction of 1,3,4-trisubstituted phosphole with aryl iodides or bromides under distinct conditions. The developed methodology is able to accommodate a wide variety of substituents, including aryl, heteroaryl, and alkenyl.

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Recent Progress Concerning the N-Arylation of Indoles

. 2021 Aug 22 ; 26 (16) : . [epub] 20210822

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