While cryptosporidiosis is recognized as being among the most common causes of human parasitic diarrhea in the world, there is currently limited knowledge on Cryptosporidium infection mechanisms, incomplete codification of diagnostic methods, and a need for additional therapeutic options. In response, the Seventh International Giardia and Cryptosporidium Conference (IGCC 2019) was hosted from 23 to 26 June 2019, at the Rouen Normandy University, France. This trusted event brought together an international delegation of researchers to synthesize recent advances and identify key research questions and knowledge gaps. The program of the interdisciplinary conference included all aspects of host-parasite relationships from basic research to applications to human and veterinary medicine, and environmental issues associated with waterborne parasites and their epidemiological consequences. In relation to Cryptosporidium and cryptosporidiosis, the primary research areas for which novel findings and the most impressive communications were presented and discussed included: Cryptosporidium in environmental waters, seafood, and fresh produce; Animal epidemiology; Human cryptosporidiosis and epidemiology; Genomes and genomic evolution encompassing: Comparative genomics of Cryptosporidium spp., Genomic insights into biology, Acquiring and utilizing genome sequences, Genetic manipulation; Host-parasite interaction (immunology, microbiome); and Diagnosis and treatment. High quality presentations discussed at the conference reflected decisive progress and identified new opportunities that will engage investigators and funding agencies to spur future research in a "one health" approach to improve basic knowledge and the clinical and public health management of zoonotic cryptosporidiosis.

TITLE: Mise à jour sur Cryptosporidium spp.: Faits saillants de la Septième Conférence Internationale sur Giardia et Cryptosporidium. ABSTRACT: Bien que la cryptosporidiose soit reconnue comme l’une des premières causes de diarrhée parasitaire humaine dans le monde, la connaissance des mécanismes de l’infection par Cryptosporidium est limitée, la codification des méthodes diagnostiques est incomplète et des options thérapeutiques supplémentaires sont requises. En réponse à cette situation, la Septième Conférence Internationale sur Giardia and Cryptosporidium (IGCC 2019) s’est tenue du 23 au 26 juin 2019, à l’Université de Rouen-Normandie, France. Cet événement renommé a rassemblé une délégation internationale de chercheurs pour faire la synthèse des avancées récentes et identifier les principaux thèmes de recherche et les lacunes dans les connaissances. Le programme de cette conférence interdisciplinaire comprenait tous les aspects des relations hôte-parasite, de la recherche fondamentale aux applications à la médecine humaine et vétérinaire, ainsi que les questions environnementales liées aux parasites d’origine hydrique et leurs conséquences épidémiologiques. En ce qui concerne Cryptosporidium et la cryptosporidiose, les principaux domaines de recherche pour lesquels de nouvelles découvertes et les communications les plus impressionnantes ont été présentées et discutées comprenaient : Cryptosporidium dans les eaux environnementales, les fruits de mer et les produits frais ; Épidémiologie animale ; Cryptosporidiose et épidémiologie humaine ; Génomes et évolution génomique englobant : Génomique comparative des Cryptosporidium spp., Perspectives génomiques en biologie, Acquisition et utilisation des séquences du génome, Manipulation génétique ; Interaction hôte-parasite (immunologie, microbiome) ; Diagnostic et traitement. Les présentations de grande qualité discutées à la conférence ont fait état de progrès décisifs et ont permis de cerner de nouvelles possibilités qui inciteront les chercheurs et les organismes de financement à stimuler la recherche future dans une approche « une seule santé » afin d’améliorer les connaissances de base et la gestion clinique et de santé publique de la cryptosporidiose zoonotique.

Center for Tropical and Emerging Global Diseases Institute of Bioinformatics and Department of Genetics University of Georgia Athens 30602 GA USA

College of Veterinary Medicine South China Agricultural University Guangzhou 510642 Guangdong PR China

Cryptosporidium Reference Unit Public Health Wales SA2 8QA Swansea UK Swansea Medical School Swansea University SA2 8PP Swansea UK

Department of Infectious Disease and Global Health Cummings School of Veterinary Medicine at Tufts University North Grafton 01536 MA USA

Department of Pathobiology School of Veterinary Medicine University of Pennsylvania 380 South University Avenue Philadelphia 19104 PA USA

French National Cryptosporidiosis Reference Center Rouen University Hospital 1 Rue de Germont 76031 Rouen Cedex France EA 7510 UFR Santé University of Rouen Normandy Normandy University 22 Bd Gambetta 76183 Rouen Cedex France

INRAE Université François Rabelais de Tours Centre Val de Loire ISP Laboratoire Apicomplexes et Immunité Mucosale 37380 Nouzilly France

Institute of Parasitology Biology Centre CAS 370 05 České Budějovice Czech Republic Faculty of Agriculture University of South Bohemia in České Budějovice 370 05 České Budějovice Czech Republic

Spanish National Centre for Microbiology 28220 Majadahonda Spain

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High Occurrence of Zoonotic Subtypes of Cryptosporidiumparvum in Cypriot Dairy Farms