Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to In Vivo Studies
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Quinones chemistry metabolism pharmacology MeSH
- HeLa Cells MeSH
- Humans MeSH
- Ligands MeSH
- Mice, Nude MeSH
- Mice MeSH
- Oxidation-Reduction drug effects MeSH
- Antineoplastic Agents chemistry metabolism pharmacology MeSH
- Ruthenium chemistry metabolism pharmacology MeSH
- Cell Survival drug effects physiology MeSH
- Xenograft Model Antitumor Assays methods MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Quinones MeSH
- Ligands MeSH
- Antineoplastic Agents MeSH
- Ruthenium MeSH
Chemotherapy remains one of the dominant treatments to cure cancer. However, due to the many inherent drawbacks, there is a search for new chemotherapeutic drugs. Many classes of compounds have been investigated over the years to discover new targets and synergistic mechanisms of action including multicellular targets. In this work, we designed a new chemotherapeutic drug candidate against cancer, namely, [Ru(DIP)2(sq)](PF6) (Ru-sq) (DIP = 4,7-diphenyl-1,10-phenanthroline; sq = semiquinonate ligand). The aim was to combine the great potential expressed by Ru(II) polypyridyl complexes and the singular redox and biological properties associated with the catecholate moiety. Experimental evidence (e.g., X-ray crystallography, electron paramagnetic resonance, electrochemistry) demonstrates that the semiquinonate is the preferred oxidation state of the dioxo ligand in this complex. The biological activity of Ru-sq was then scrutinized in vitro and in vivo, and the results highlight the promising potential of this complex as a chemotherapeutic agent against cancer.
Department of Chemistry University of Konstanz Universitätsstrasse 10 D 78457 Konstanz Germany
Department of Chemistry University of Zurich Winterthurerstrasse 190 8057 Zurich Switzerland
Institut Curie PSL University CNRS UMR 144 F 75005 Paris France
Institute of Molecular Cancer Research University of Zurich CH 8057 Zurich Switzerland
Université de Paris Institut de physique du Globe de Paris CNRS F 75005 Paris France
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