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PubMed

Záznam pochází z PubMed

Age-Related Variations in Takotsubo Syndrome

Journal of the American College of Cardiology. 2020 Apr 28 ; 75 (16) : 1869-1877.

J Am Coll Cardiol
ISSN 1558-3597 | 0735-1097
Zdroj

Jazyk angličtina Země Spojené státy americké Médium print

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz https://www.medvik.cz/link/pmid32327096

PubMed 32327096
DOI 10.1016/j.jacc.2020.02.057
PII: S0735-1097(20)34466-1
Knihovny.cz E-zdroje

Klíčová slova
Takotsubo syndrome, age, broken heart syndrome, outcome,
MeSH
celosvětové zdraví MeSH
duševní poruchy epidemiologie MeSH
hodnocení rizik statistika a číselné údaje MeSH
kardiogenní šok * epidemiologie etiologie MeSH
kauzalita MeSH
lidé středního věku MeSH
lidé MeSH
mortalita v nemocnicích * MeSH
mortalita MeSH
nemoci nervového systému epidemiologie MeSH
prevalence MeSH
prognóza MeSH
registrace MeSH
senioři MeSH
takotsubo kardiomyopatie * komplikace diagnóza epidemiologie patofyziologie MeSH
věk při počátku nemoci * MeSH
věkové faktory * MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

BACKGROUND: Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients. OBJECTIVES: This study aimed to investigate age-related differences in TTS. METHODS: Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: ≤50 years, middle-age: 51 to 74 years, elderly: ≥75 years). Baseline characteristics, hospital course, as well as short- and long-term mortality were compared among groups. RESULTS: Of 2,098 TTS patients, 242 (11.5%) patients were ≤50 years of age, 1,194 (56.9%) were 51 to 74 years of age, and 662 (31.6%) were ≥75 years of age. Younger patients were more often men (12.4% vs. 10.9% vs. 6.3%; p = 0.002) and had an increased prevalence of acute neurological (16.3% vs. 8.4% vs. 8.8%; p = 0.001) or psychiatric disorders (14.1% vs. 10.3% vs. 5.6%; p < 0.001) compared with middle-aged and elderly TTS patients. Furthermore, younger patients had more often cardiogenic shock (15.3% vs. 9.1% vs. 8.1%; p = 0.004) and had a numerically higher in-hospital mortality (6.6% vs. 3.6% vs. 5.1%; p = 0.07). At multivariable analysis, younger (odds ratio: 1.60; 95% confidence interval: 0.86 to 3.01; p = 0.14) and older age (odds ratio: 1.09; 95% confidence interval: 0.66 to 1.80; p = 0.75) were not independently associated with in-hospital mortality using the middle-aged group as a reference. There were no differences in 60-day mortality rates among groups. CONCLUSIONS: A substantial proportion of TTS patients are younger than 50 years of age. TTS is associated with severe complications requiring intensive care, particularly in younger patients.

Age-Related Variations in Takotsubo Syndrome

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