The 7-chloro-4-(piperazin-1-yl)quinoline structure is an important scaffold in medicinal chemistry. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacological profiles such as: antimalarial, antiparasitic, anti-HIV, antidiabetic, anticancer, sirtuin Inhibitors, dopamine-3 ligands, acetylcholinesterase inhibitors, and serotonin antagonists. In the presented review, a comprehensive discussion of compounds having this structural core is surveyed and illustrated.

Department of Biomolecular Spectroscopy Institute of Organic Chemistry and Biochemistry Academy of Sciences Prague Czech Republic

Department of Chemistry of Natural Compounds Faculty of Food and Biochemical Technology University of Chemistry and Technology Prague Czech Republic

Medicinal and Pharmaceutical Chemistry Department Pharmaceutical and Drug Industries Research Division National Research Centre Giza Egypt

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