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Článek

PubMed

Záznam pochází z PubMed

Coexistence and outcome of coronary artery disease in Takotsubo syndrome

European heart journal. 2020 Sep 07 ; 41 (34) : 3255-3268.

Eur Heart J
ISSN 1522-9645 | 0195-668X
Zdroj

Jazyk angličtina Země Velká Británie, Anglie Médium print

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz https://www.medvik.cz/link/pmid32484517

PubMed 32484517
DOI 10.1093/eurheartj/ehaa210
PII: 5850330
Knihovny.cz E-zdroje

Klíčová slova
Cardiac catheterization, Acute coronary syndrome, Coronary artery disease, Myocardial infarction, Outcome, Takotsubo syndrome,
MeSH
akutní koronární syndrom * MeSH
incidence MeSH
koronární angiografie MeSH
lidé MeSH
nemoci koronárních tepen * komplikace diagnostické zobrazování MeSH
takotsubo kardiomyopatie * komplikace epidemiologie MeSH
Check Tag
lidé MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

AIMS: Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a large cohort of patients with TTS. METHODS AND RESULTS: Coronary anatomy and CAD were studied in patients diagnosed with TTS. Inclusion criteria were compliance with the International Takotsubo Diagnostic Criteria for TTS, and availability of original coronary angiographies with ventriculography performed during the acute phase. Exclusion criteria were missing views, poor quality of angiography loops, and angiography without ventriculography. A total of 1016 TTS patients were studied. Of those, 23.0% had obstructive CAD, 41.2% had non-obstructive CAD, and 35.7% had angiographically normal coronary arteries. A total of 47 patients (4.6%) underwent percutaneous coronary intervention, and 3 patients had acute and 8 had chronic coronary artery occlusion concomitant with TTS, respectively. The presence of CAD was associated with increased incidence of shock, ventilation, and death from any cause. After adjusting for confounders, the presence of obstructive CAD was associated with mortality at 30 days. Takotsubo syndrome patients with obstructive CAD were at comparable risk for shock and death and nearly at twice the risk for ventilation compared to an age- and sex-matched ACS cohort. CONCLUSIONS: Coronary artery disease frequently coexists in TTS patients, presents with the whole spectrum of coronary pathology including acute coronary occlusion, and is associated with adverse outcome. TRIAL REGISTRATION: ClinicalTrials.gov number: NCT01947621.

Coexistence and outcome of coronary artery disease in Takotsubo syndrome

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