Serum Bilirubin in the Czech Population - Relationship to the Risk of Myocardial Infarction in Males
Language English Country Japan Media print-electronic
Document type Journal Article
- Keywords
- Bilirubin, Cardiovascular diseases, Gilbert syndrome, Myocardial infarction, UGT1A1 promoter gene variants,
- MeSH
- Bilirubin blood MeSH
- Adult MeSH
- Genotype MeSH
- Gilbert Disease blood epidemiology genetics MeSH
- Glucuronosyltransferase genetics MeSH
- Myocardial Infarction blood epidemiology genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Polymorphism, Genetic MeSH
- Prevalence MeSH
- Promoter Regions, Genetic MeSH
- Prospective Studies MeSH
- Cross-Sectional Studies MeSH
- Retrospective Studies MeSH
- Risk Factors MeSH
- Sex Factors MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- Bilirubin MeSH
- Glucuronosyltransferase MeSH
- UGT1A1 enzyme MeSH Browser
BACKGROUND: The potential antiatherogenic role of bilirubin is generally acknowledged, so the aim of this study was to determine serum bilirubin concentrations and the prevalence of Gilbert syndrome (GS) in the Czech general population with particular reference to its relationship to the risk of myocardial infarction (MI). METHODS AND RESULTS: Biochemical markers were analyzed in 2 independent Czech post-MONICA studies (in total, n=3,311), and in 741 male MI patients. TheUGT1A1promoter gene variant (rs81753472) was analyzed in these MI patients and in the first control population cohort (n=717). Medians of serum bilirubin concentrations in the 2 Czech general population cohorts were 9.6 and 9.8 μmol/L (10.7 and 11.3 μmol/L in males, and 8.3 and 8.8 μmol/L in females; P<0.01). The prevalence of GS was 8.9%, twice as high in males compared with females (11.6 vs. 6.1%; P<0.01). TheUGT1A1(TA)7/7promoter repeats significantly influenced serum bilirubin concentrations in the controls, but not in the MI patients. Serum bilirubin concentrations were significantly lower in MI patients (7.7 vs. 10.7 μmol/L; P<0.01), with almost 5-fold lower prevalence of GS. CONCLUSIONS: Serum bilirubin concentrations and the prevalence of GS were determined in the Czech general population. Significantly lower serum bilirubin concentrations were observed in male MI patients.
Center for Experimental Medicine Institute for Clinical and Experimental Medicine
Department of Preventive Cardiology Institute for Clinical and Experimental Medicine
Medical Statistics Unit Institute for Clinical and Experimental Medicine
References provided by Crossref.org
The physiology of bilirubin: health and disease equilibrium
Serum Bilirubin Concentrations and the Prevalence of Gilbert Syndrome in Elite Athletes
