Serum Bilirubin in the Czech Population - Relationship to the Risk of Myocardial Infarction in Males
Jazyk angličtina Země Japonsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
32848115
DOI
10.1253/circj.cj-20-0192
Knihovny.cz E-zdroje
- Klíčová slova
- Bilirubin, Cardiovascular diseases, Gilbert syndrome, Myocardial infarction, UGT1A1 promoter gene variants,
- MeSH
- bilirubin krev MeSH
- dospělí MeSH
- genotyp MeSH
- Gilbertova nemoc krev epidemiologie genetika MeSH
- glukuronosyltransferasa genetika MeSH
- infarkt myokardu krev epidemiologie genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- polymorfismus genetický MeSH
- prevalence MeSH
- promotorové oblasti (genetika) MeSH
- prospektivní studie MeSH
- průřezové studie MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- sexuální faktory MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- bilirubin MeSH
- glukuronosyltransferasa MeSH
- UGT1A1 enzyme MeSH Prohlížeč
BACKGROUND: The potential antiatherogenic role of bilirubin is generally acknowledged, so the aim of this study was to determine serum bilirubin concentrations and the prevalence of Gilbert syndrome (GS) in the Czech general population with particular reference to its relationship to the risk of myocardial infarction (MI). METHODS AND RESULTS: Biochemical markers were analyzed in 2 independent Czech post-MONICA studies (in total, n=3,311), and in 741 male MI patients. TheUGT1A1promoter gene variant (rs81753472) was analyzed in these MI patients and in the first control population cohort (n=717). Medians of serum bilirubin concentrations in the 2 Czech general population cohorts were 9.6 and 9.8 μmol/L (10.7 and 11.3 μmol/L in males, and 8.3 and 8.8 μmol/L in females; P<0.01). The prevalence of GS was 8.9%, twice as high in males compared with females (11.6 vs. 6.1%; P<0.01). TheUGT1A1(TA)7/7promoter repeats significantly influenced serum bilirubin concentrations in the controls, but not in the MI patients. Serum bilirubin concentrations were significantly lower in MI patients (7.7 vs. 10.7 μmol/L; P<0.01), with almost 5-fold lower prevalence of GS. CONCLUSIONS: Serum bilirubin concentrations and the prevalence of GS were determined in the Czech general population. Significantly lower serum bilirubin concentrations were observed in male MI patients.
Center for Experimental Medicine Institute for Clinical and Experimental Medicine
Department of Preventive Cardiology Institute for Clinical and Experimental Medicine
Medical Statistics Unit Institute for Clinical and Experimental Medicine
Citace poskytuje Crossref.org
The physiology of bilirubin: health and disease equilibrium
Serum Bilirubin Concentrations and the Prevalence of Gilbert Syndrome in Elite Athletes
