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Sensors and microarrays in protein biomarker monitoring: an electrochemical perspective spots

. 2020 Sep ; 12 (18) : 1337-1345. [epub] 20200911

Language English Country Great Britain, England Media print-electronic

Document type Journal Article

Grant support
CA16113 European cooperation in science and technology - COST CliniMARK: 'good biomarker practice' to increase the number of clinically validated biomarkers

The development of clinically applicable portable sensors and multiplex protein biomarker assays is one of the most important goals of laboratory medicine today. Sensing strategies based on electrochemical devices are discussed in this overview, with special emphasis on detection principles derived from voltammetry, electrogenerated chemiluminescence, bipolar electrochemistry and impedance-based measurements. Up-to-date examples of electrochemical methods in biomedical research and development are highlighted here, including critical evaluation and future directions of the analysis, development and validation of new protein biomarkers.

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