Reference values of retinal microcirculation parameters derived from a population random sample
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
33245956
DOI
10.1016/j.mvr.2020.104117
PII: S0026-2862(20)30177-1
Knihovny.cz E-zdroje
- Klíčová slova
- Czech post-MONICA study, Juxtapapillary retinal capillary blood flow, Luminal diameter, Retinal vascular resistance, Scanning laser Doppler flowmetry, Vessel diameter, Wall cross-sectional area, Wall thickness, Wall-to-lumen ratio,
- MeSH
- běloši MeSH
- dospělí MeSH
- krevní tlak MeSH
- laser doppler flowmetrie * MeSH
- lidé středního věku MeSH
- lidé MeSH
- mikrocirkulace * MeSH
- prediktivní hodnota testů MeSH
- průřezové studie MeSH
- rasové faktory MeSH
- referenční hodnoty MeSH
- regionální krevní průtok MeSH
- remodelace cév MeSH
- retinální cévy patofyziologie MeSH
- rychlost toku krve MeSH
- senioři MeSH
- tuhost cévní stěny MeSH
- věkové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
Retinal microcirculation reflects retinal perfusion abnormalities and retinal arterial structural changes at relatively early stages of various cardiovascular diseases. Our objective has been to establish reference values for major functional and structural parameters of retinal microcirculation in a randomly selected urban population sample. A total of 398 randomly selected individuals from an urban population aged 25 to 65 years, resident in Pilsen, Czech Republic, were screened for major cardiovascular risk factors. Retinal microcirculation was assessed using scanning laser Doppler flowmetry (SLDF), with data evaluable in 343 patients. Of this number, complete data were available for 256 individuals free from manifest cardiovascular disease, diabetes and drug treatment for hypertension and/or dyslipidemia, constituting the reference value population. Juxtapapillary retinal capillary blood flow has increased significantly with age whereas vessel and luminal diameters have decreased. No sex differences in retinal microcirculation parameters have been found. Therefore, reference values for retinal microcirculation parameters have been established by age groups. Unattended automated office systolic BP, after adjusting for age, correlated significantly with wall-to-lumen ratio (WLR) and wall thickness (WT). Moreover, after adjusting for age and mean BP, a positive relationship has been found between carotid femoral pulse wave velocity and WT, WLR and wall cross-sectional area, indicating the interaction between micro- and macro-vasculature. In conclusion, our study is the first to provide reference values of retinal microcirculation parameters in a random Caucasian population sample. Our results have shown that, at the population level, the first structural changes in retinal microcirculation are those in lumen diameters. Of note, a close relationship between BP and vascular remodeling of retinal arterioles and between aortic stiffness and WLR of retinal arterioles suggests an interaction between micro- and macro-vasculature.
2nd Department of Internal Medicine Faculty of Medicine Charles University Pilsen Czech Republic
Department of Nephrology and Hypertension Friedrich Alexander University Erlangen Nürnberg Germany
Medical Statistics Unit Institute for Clinical and Experimental Medicine Prague Czech Republic
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