This Special Issue of International Journal of Molecular Sciences (IJMS) contains 7 reviews and 12 original research papers written by a panel of experts who highlight recent advances in molecular structure and cellular function of purinergic P2 receptors[...].

Institute of Physiology Czech Academy of Sciences 14220 Prague Czech Republic

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Peralta F.A., Huidobro-Toro J.P. New Insights of the Zn(II)-Induced P2X4R Positive Allosteric Modulation: Role of Head Receptor Domain SS2/SS3, E160 and D170. Int. J. Mol. Sci. 2020;21:6940. doi: 10.3390/ijms21186940. PubMed DOI PMC

Popova M., Rodriguez L., Trudell J.R., Nguyen S., Bloomfield M., Davies D.L., Asatryan L. Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity. Int. J. Mol. Sci. 2020;21:2471. doi: 10.3390/ijms21072471. PubMed DOI PMC

Rupert M., Bhattacharya A., Stillerova V.T., Jindrichova M., Mokdad A., Boué-Grabot E., Zemkova H. Role of Conserved Residues and F322 in the Extracellular Vestibule of the Rat P2X7 Receptor in Its Expression, Function and Dye Uptake Ability. Int. J. Mol. Sci. 2020;21:8446. doi: 10.3390/ijms21228446. PubMed DOI PMC

Bautista-Pérez R., Pérez-Méndez O., Agustina C.-M., Pacheco U., Santamaría J., Rodríguez-Sámano F., Rodriguez-Iturbe B., Navar L.G., Franco M. The Role of P2X7 Purinergic Receptors in the Renal Inflammation Associated with Angiotensin II-Induced Hypertension. Int. J. Mol. Sci. 2020;21:4041. doi: 10.3390/ijms21114041. PubMed DOI PMC

Wilkaniec A., Cieslik M., Murawska E., Babiec L., Gassowska-Dobrowolska M., Palasz E., Jesko H., Adamczyk A. P2X7 Receptor Is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells. Int. J. Mol. Sci. 2020;21:3959. doi: 10.3390/ijms21113959. PubMed DOI PMC

Miteva A., Gaydukov A., Balezina O. Interaction between Calcium Chelators and the Activity of P2X7 Receptors in Mouse Motor Synapses. Int. J. Mol. Sci. 2020;21:2034. doi: 10.3390/ijms21062034. PubMed DOI PMC

Koldej R.M., Perera T., Collins J., Ritchie D.S. Association between P2X7 Polymorphisms and Post-Transplant Outcomes in Allogeneic Haematopoietic Stem Cell Transplantation. Int. J. Mol. Sci. 2020;21:3772. doi: 10.3390/ijms21113772. PubMed DOI PMC

Zhang Y., Babczyk P., Pansky A., Kassack M.U., Tobiasch E. P2 Receptors Influence hMSCs Differentiation Towards Endothelial Cell and Smooth Muscle Cell Lineages. Int. J. Mol. Sci. 2020;21:6210. doi: 10.3390/ijms21176210. PubMed DOI PMC

Christensen M.G., Johnsen N., Skals M., Hamilton A.D.M., Rubak P., Hvas A.M., Praetorius H. Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in A Murine Model of Urosepsis. Int. J. Mol. Sci. 2020;21:5652. doi: 10.3390/ijms21165652. PubMed DOI PMC

Velazquez-Miranda E., Molina-Aguilar C., Gonzalez-Gallardo A., Vazquez-Martinez O., Diaz-Munoz M., Vazquez-Cuevas F.G. Increased Purinergic Responses Dependent on P2Y2 Receptors in Hepatocytes from CCl4-Treated Fibrotic Mice. Int. J. Mol. Sci. 2020;21:2305. doi: 10.3390/ijms21072305. PubMed DOI PMC

Mikolajewicz N., Komarova S.V. Role of UDP-Sugar Receptor P2Y14 in Murine Osteoblasts. Int. J. Mol. Sci. 2020;21:2747. doi: 10.3390/ijms21082747. PubMed DOI PMC

Schreiber R., Ousingsawat J., Kunzelmann K. Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling. Int. J. Mol. Sci. 2020;21:4065. doi: 10.3390/ijms21114065. PubMed DOI PMC

Strassheim D., Verin A., Batori R., Nijmeh H., Burns N., Kovacs-Kasa A., Umapathy N.S., Kotamarthi J., Gokhale Y.S., Karoor V., et al. P2Y Purinergic Receptors, Endothelial Dysfunction, and Cardiovascular Diseases. Int. J. Mol. Sci. 2020;21:6855. doi: 10.3390/ijms21186855. PubMed DOI PMC

Wirsching E., Fauler M., Fois G., Frick M. P2 Purinergic Signaling in the Distal Lung in Health and Disease. Int. J. Mol. Sci. 2020;21:4973. doi: 10.3390/ijms21144973. PubMed DOI PMC

Ali A.A.H., Avakian G.A., Von Gall C. The Role of Purinergic Receptors in the Circadian System. Int. J. Mol. Sci. 2020;21:3423. doi: 10.3390/ijms21103423. PubMed DOI PMC

Rivas-Yáñez E., Barrera-Avalos C., Parra-Tello B., Briceño P., Rosemblatt M.V., Saavedra-Almarza J., Rosemblatt M., Acuña-Castillo C., Bono M.R., Sauma D. P2X7 Receptor at the Crossroads of T Cell Fate. Int. J. Mol. Sci. 2020;21:4937. doi: 10.3390/ijms21144937. PubMed DOI PMC

Panicucci C., Raffaghello L., Bruzzone S., Baratto S., Principi E., Minetti C., Gazzerro E., Bruno C. eATP/P2X7R Axis: An Orchestrated Pathway Triggering Inflammasome Activation in Muscle Diseases. Int. J. Mol. Sci. 2020;21:5963. doi: 10.3390/ijms21175963. PubMed DOI PMC

Martinez-Cuesta M.A., Blanch-Ruiz M.A., Ortega-Luna R., Sanchez-Lopez A., Alvarez A. Structural and Functional Basis for Understanding the Biological Significance of P2X7 Receptor. Int. J. Mol. Sci. 2020;21:8454. doi: 10.3390/ijms21228454. PubMed DOI PMC

Mancinelli R., Fanò-Illic G., Pietrangelo T., Fulle S. Guanosine-Based Nucleotides, the Sons of a Lesser God in the Purinergic Signal Scenario of Excitable Tissues. Int. J. Mol. Sci. 2020;21:1591. doi: 10.3390/ijms21051591. PubMed DOI PMC