A European consensus conference on endometrial carcinoma was held in 2014 to produce multidisciplinary evidence-based guidelines on selected questions. Given the large body of literature on the management of endometrial carcinoma published since 2014, the European Society of Gynaecological Oncology (ESGO), the European SocieTy for Radiotherapy & Oncology (ESTRO) and the European Society of Pathology (ESP) jointly decided to update these evidence-based guidelines and to cover new topics in order to improve the quality of care for women with endometrial carcinoma across Europe and worldwide. ESGO/ESTRO/ESP nominated an international multidisciplinary development group consisting of practicing clinicians and researchers who have demonstrated leadership and expertise in the care and research of endometrial carcinoma (27 experts across Europe). To ensure that the guidelines are evidence-based, the literature published since 2014, identified from a systematic search was reviewed and critically appraised. In the absence of any clear scientific evidence, judgment was based on the professional experience and consensus of the development group. The guidelines are thus based on the best available evidence and expert agreement. Prior to publication, the guidelines were reviewed by 191 independent international practitioners in cancer care delivery and patient representatives. The guidelines comprehensively cover endometrial carcinoma staging, definition of prognostic risk groups integrating molecular markers, pre- and intra-operative work-up, fertility preservation, management for early, advanced, metastatic, and recurrent disease and palliative treatment. Principles of radiotherapy and pathological evaluation are also defined.

Clinical research Unit Institut Bergonie Bordeaux France

Corporate Member of Freie Universität Berlin Humboldt Universität zu Berlin and Berlin Institute of Health Berlin Germany

Department of Gynaecologic Oncology Imperial College London Faculty of Medicine London UK

Department of Gynaecology Royal Marsden Hospital London UK

Department of Gynecology and Obstetrics Gynecologic Oncology Leuven Cancer Institute Catholic University Leuven Leuven Belgium

Department of Gynecology and Obstetrics Innsbruck Medical University Innsbruck Austria

Department of Gynecology and Obstetrics TU Dresden Medizinische Fakultat Carl Gustav Carus Dresden Germany

Department of Gynecology with Center for Oncological Surgery Campus Virchow Klinikum Charité Universitätsmedizin Berlin Berlin Germany

Department of Medical Oncology Amsterdam University Medical Centres Amsterdam Noord Holland The Netherlands

Department of Medical Oncology Clinica Universidad de Navarra Madrid Spain

Department of Medical Oncology St James Hospital Dublin Ireland

Department of Obstetrics and Gynecologic Oncology University Hospital Strasbourg France

Department of Obstetrics and Gynecology 1st Faculty of Medicine Charles University General University Hospital Prague Prague Czech Republic

Department of Obstetrics and Gynecology Innsbruck Medical University Innsbruck Austria

Department of Oncology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark

Department of Pathology Hospital Graz 2 Graz Austria

Department of Pathology Hospital Universitari Arnau de Vilanova University of Lleida CIBERONC Irblleida Spain

Department of Pathology Hospital Universitari de Bellvitge University of Barcelona Idibell Spain

Department of Pathology Leids Universitair Medisch Centrum Leiden The Netherlands

Department of Radiation Oncology Comprehensive Cancer Center Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology Medical University of Vienna Vienna Austria

Department of Radiation Oncology Institut Gustave Roussy Villejuif France

Department of Radiation Oncology Leiden University Medical Center Leiden The Netherlands

Department of Radiation Oncology Medical Faculty of the University of Cologne Cologne Germany

Department of Radiotherapy Erasmus MC Cancer Institute Rotterdam The Netherlands

Department of Surgery Institut Gustave Roussy Villejuif France

Division of Gynecologic Oncology Fondazione Policlinico Universitario A Gemelli IRCCS Roma Italy

Evangelische Kliniken Essen Mitte Essen Germany

Gynecologic Oncology Program European Institute of Oncology IRCCS Milan and University of Milan Bicocca Milan Italy

Histopathology and Molecular Diagnostics Azienda Ospedaliero Universitaria Careggi Florence Italy

School of Medicine Johannes Kepler University Linz Linz Austria

UCL Cancer Institute University College London UK

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