Antibiotic susceptibility screening of primate-associated Clostridium ventriculi
Language English Country England, Great Britain Media print-electronic
Document type Comparative Study, Journal Article
PubMed
33607254
DOI
10.1016/j.anaerobe.2021.102347
PII: S1075-9964(21)00030-5
Knihovny.cz E-resources
- Keywords
- Antibiotics, Disk diffusion, Monkeys, Resistance, Sarcina ventriculi, Susceptibility,
- MeSH
- Anti-Bacterial Agents therapeutic use MeSH
- Clostridium drug effects genetics MeSH
- Genetic Variation MeSH
- Genotype MeSH
- Haplorhini microbiology MeSH
- Hylobates microbiology MeSH
- Clostridium Infections diagnosis drug therapy MeSH
- Primates microbiology MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
Clostridium ventriculi (syn. Sarcina ventriculi) is a Gram-positive opportunistic pathogen with sarcina morphology. In the case of gastrointestinal disorders, the treatment is often empirical. Due to the common occurrence in primates and the potential risk of dysbiosis; the antibiotic susceptibility screening of C. ventriculi strains isolated from guenon monkeys and crested gibbons to 58 antibiotics was performed to reduce potentially ineffective antibiotic use in case of disease. Isolates were found to be susceptible to the majority of the tested antibiotics, mainly to (fluoro)quinolones, macrolides, penicillins, and tetracyclines. The susceptibility profiles were similar despite the hosts. Tested strains showed also natural resistance to a few antibiotics on the genus level. Detected in vitro antibiotic efficiency is consistent with documented human treatment cases.
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