Soft tissue sarcomas in the head and neck are rare malignancies. They occur in this area in less than 1% of all malignant tumors. Some authors have described the development of sarcoma from the mesenchymal tissue in the larynx. The histological diagnosis of a sarcoma depends on the immunohistochemical investigation. In particularly difficult diagnoses, electron microscopy has to be used. The treatment recommendation depends on the histological type of sarcoma. We analysed and summarized data on the diagnostic criteria and therapy for sarcoma of the larynx presented in the literature. We present three new cases of laryngeal sarcoma and describe the analyses of the published diagnostic and treatment schedules of laryngeal sarcomas. We developed a treatment protocol recommendation for laryngeal sarcoma based on an analysis of literature data and case reports. This recommendation is based on histological type, staging, grading, size, and survival data.

1st Faculty of Medicine Charles University 12108 Prague Czech Republic

3rd Faculty of Medicine Charles University 10000 Prague Czech Republic

Department of Otolaryngology Institute of Postgradual Medical Education 10005 Prague Czech Republic

Department of Otorhinolaryngology and Maxillofacial Surgery Military University Hospital 16902 Prague Czech Republic

Department of Pathology Military University Hospital 16902 Prague Czech Republic

Department of Radiology Military University Hospital 16902 Prague Czech Republic

Institute of Radiation Oncology Bulovka University Hospital 18081 Prague Czech Republic

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