Design, synthesis, and antiproliferative effect of 2,9-bis[4-(pyridinylalkylaminomethyl)phenyl]-1,10-phenanthroline derivatives on human leukemic cells by targeting G-quadruplex
Language English Country Germany Media print-electronic
Document type Journal Article
- Keywords
- 1, 10-phenanthroline, FRET melting, G-quadruplex, G4 ligands, antiproliferative activity, leukemia,
- MeSH
- Leukemia, Myeloid, Acute drug therapy pathology MeSH
- K562 Cells MeSH
- Phenanthrolines chemical synthesis chemistry pharmacology MeSH
- G-Quadruplexes drug effects MeSH
- HL-60 Cells MeSH
- Humans MeSH
- Ligands MeSH
- Cell Line, Tumor MeSH
- Antineoplastic Agents chemical synthesis chemistry pharmacology MeSH
- Drug Design MeSH
- Fluorescence Resonance Energy Transfer MeSH
- Telomerase metabolism MeSH
- U937 Cells MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- 1,10-phenanthroline MeSH Browser
- Phenanthrolines MeSH
- Ligands MeSH
- Antineoplastic Agents MeSH
- Telomerase MeSH
Current multiagent chemotherapy regimens have improved the cure rate in acute leukemia patients, but they are highly toxic and poorly efficient in relapsed patients. To improve the treatment approaches, new specific molecules are needed. The G-quadruplexes (G4s), which are noncanonical nucleic acid structures found in specific guanine-rich DNA or RNA, are involved in many cellular events, including control of gene expression. G4s are considered as targets for the development of anticancer agents. Heterocyclic molecules are well known to target and stabilize G4 structures. Thus, a new series of 2,9-bis[(substituted-aminomethyl)phenyl]-1,10-phenanthroline derivatives (1a-i) was designed, synthesized, and evaluated against five human myeloid leukemia cell lines (K562, KU812, MV4-11, HL60, and U937). Their ability to stabilize various oncogene promoter G4 structures (c-MYC, BCL-2, and K-RAS) as well as the telomeric G4 was also determined through the fluorescence resonance energy transfer melting assay and native mass spectrometry. In addition, the more bioactive ligands 1g-i were tested for telomerase activity in HuT78 and MV4-11 protein extracts.
IECB Université Bordeaux CNRS INSERM UMS 3033 US001 Pessac France
Institute of Biophysics Czech Academy of Sciences v v i Brno Czech Republic
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