OBJECTIVE: Oncocytic papillary cystadenomas (OPCs) of the larynx are rare benign cystic lesions that usually present as supraglottic masses arising from the laryngeal ventricles. OPCs are found in patients older than 60 years, with a female predominance. Symptoms vary from asymptomatic to hoarseness, dyspnea, and dysphagia; often, they mimic a laryngocele. The treatment is surgical. Diagnosis is based on histopathologic examination. MATERIALS AND METHODS: Surgical records for laryngeal masses diagnosed between 2005 and 2020 were searched retrospectively. RESULTS: Ten patients were identified and included in the study. OPCs predominantly occurred in women (9/10), and the mean age at presentation was 73 years. Most patients (8/10) presented with hoarseness and were smokers. OPCs were localized in the ventricle in eight out of ten patients. Surgical treatment was performed in all cases, mostly using transoral endolaryngeal approach (9/10). Histopathologic examination revealed oncocytic cyst or oncocytic papillary cystadenoma (the former term being the older synonym for OPC). CONCLUSION: OPCs present a separate clinicopathologic entity, distinct from other cystic laryngeal lesions. They have a characteristic location, age and sex group, microscopic appearance, and potential for local recurrence.

Department of Otorhinolaryngology and Head and Neck Surgery 1st Faculty of Medicine Charles University University Hospital Motol 5 Uvalu 84 15006 Prague Czech Republic

Department of Otorhinolaryngology and Head and Neck Surgery Faculty of Medicine in Hradec Kralove Charles University University Hospital Hradec Kralove Hradec Kralove Czech Republic

The Fingerland Department of Pathology Faculty of Medicine in Hradec Kralove Charles University University Hospital Hradec Kralove Hradec Kralove Czech Republic

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Koschier H (1897) Ueber prolapsus sinus Morgagni. Wien Klin Wochenschr 10:815–820

Steglich-Petersen J (1966) Eosinophilic papillary cystadenoma of the larynx. Acta Otolaryngol 62(6):505–512. https://doi.org/10.3109/00016486609119594 PubMed DOI

Salerno G, Mignogna C, Cavaliere M, D’Angelo L, Galli V (2007) Oncocytic cyst of the larynx: an unusual occurrence. Acta Otorhinolaryngol Ital 27(4):212–215 PubMed PMC

Salvador P, Moreira da Silva F, Fonseca R (2020) Laryngeal oncocytic cystadenoma mimicking a combined laryngomucocele. BMJ Case Rep. https://doi.org/10.1136/bcr-2020-236866 PubMed DOI

Stenner M, Muller KM, Koopmann M, Rudack C (2014) Squamous cell carcinoma of the larynx arising in multifocal pharyngolaryngeal oncocytic papillary cystadenoma: a case report and review of the literature. Medicine (Baltimore) 93(12):e70. https://doi.org/10.1097/MD.0000000000000070 DOI

Peeters A, Schmelzer B, Beernaert A, Fannes H (2001) Oncocytic laryngeal cysts: a case report and literature review. Acta Otorhinolaryngol Belg 55(1):71–75 PubMed

Brandwein M, Huvos A (1995) Laryngeal oncocytic cystadenomas. Eight cases and a literature review. Arch Otolaryngol Head Neck Surg 121(11):1302–1305 DOI

Ali TA, Sabah BA, Gopalan K (2013) Papillary cystadenoma of larynx: a case report. Int J Otolaryngol Head Neck Surg 2(6):280–285. https://doi.org/10.4236/ijohns.2013.26058 DOI

Newman BH, Taxy JB, Laker HI (1984) Laryngeal cysts in adults: a clinicopathologic study of 20 cases. Am J Clin Pathol 81(6):715–720. https://doi.org/10.1093/ajcp/81.6.715 PubMed DOI

Gallagher JC, Puzon BQ (1969) Oncocytic lesions of the larynx. Ann Otol Rhinol Laryngol 78(2):307–318. https://doi.org/10.1177/000348946907800210 PubMed DOI

Yamase HT, Putman HC 3rd (1979) Oncocytic papillary cystadenomatosis of the larynx: a clinicopathologic entity. Cancer 44(6):2306–2311 DOI

LeJeune FE Jr, Putman HC 3rd, Yamase HT (1980) Multiple oncocytic papillary cystadenomas of the larynx: a case report. Laryngoscope 90(3):501–504. https://doi.org/10.1002/lary.5540900318 PubMed DOI

Ferlito A, Recher G (1981) Oncocytic lesions of the larynx. Arch Otorhinolaryngol 232(2):107–115. https://doi.org/10.1007/BF00505029 PubMed DOI

Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbaren P, Skalova A, Rinaldo A, Ferlito A (2019) Analysis of the clinical relevance of histological classification of benign epithelial salivary gland tumours. Adv Ther 36(8):1950–1974. https://doi.org/10.1007/s12325-019-01007-3 PubMed DOI PMC

Chin S, Kim HK, Kwak JJ (2014) Oncocytic papillary cystadenoma of major salivary glands: three rare cases with diverse cytologic features. J Cytol 31(4):221–223. https://doi.org/10.4103/0970-9371.151140 PubMed DOI PMC

Goto M, Ohnishi Y, Shoju Y, Wato M, Kakudo K (2016) Papillary oncocytic cystadenoma of a palatal minor salivary gland: a case report. Oncol Lett 11(2):1220–1222. https://doi.org/10.3892/ol.2015.3978 PubMed DOI

Lundgren J, Olofsson J, Hellquist H (1982) Oncocytic lesions of the larynx. Acta Otolaryngol 94(3–4):335–344. https://doi.org/10.3109/00016488209128921 PubMed DOI

Bell RD, Chamberlain D, Jahn AF (1978) Oncocytic lesions of the larynx. J Otolaryngol 7(3):211–217 PubMed

Friedman L, Patel M, Steinberg J, Hardy D (1990) CT appearance of an oncocytic papillary cystadenoma of the larynx. J Comput Assist Tomogr 14(2):322–324. https://doi.org/10.1097/00004728-199003000-00036 PubMed DOI

Feinstein AJ, Peng KA, Bhuta SM, Abemayor E, Mendelsohn AH (2016) Laryngeal oncocytic cystadenomas masquerading as laryngoceles. Am J Otolaryngol 37(1):17–21. https://doi.org/10.1016/j.amjoto.2015.09.010 PubMed DOI

Brandenburg JH (1967) Oncocytic cyst of the larynx. Ann Otol Rhinol Laryngol 76(1):220–223. https://doi.org/10.1177/000348946707600117 PubMed DOI

Martin-Hirsch DP, Lannigan FJ, Irani B, Batman P (1992) Oncocytic papillary cystadenomatosis of the larynx. J Laryngol Otol 106(7):656–658. https://doi.org/10.1017/s0022215100120456 PubMed DOI