The important participation of sympathetic nervous system in various forms of experimental hypertension is well known. This is also true for salt hypertension elicited by excess salt intake in Dahl salt-sensitive rats (for review see Zicha et al. 2012). Two recent studies in Dahl rats (Zicha et al. 2019, Puleo et al. 2020) evaluated the hypothesis on the role of beta-adrenergic WNK4-NCC pathway in salt-sensitive hypertension which has been proposed by Mu et al. (2011). Although these studies differed in many experimental details, both of them demonstrated a major importance of alpha1- rather than beta-adrenergic mechanisms for the development of salt hypertension in this rat strain.

Institute of Physiology Czech Academy of Sciences Prague Czech Republic

Hypertension. 2020 Nov;76(5):1461-1469. doi: 10.1161/HYPERTENSIONAHA.120.15928. PubMed

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