Contribution of sympathetic nervous system to high blood pressure in salt hypertensive dahl rats
Jazyk angličtina Země Česko Médium print
Typ dokumentu úvodníky, komentáře
PubMed
33992042
PubMed Central
PMC8820575
DOI
10.33549/physiolres.934678
PII: 934678
Knihovny.cz E-zdroje
- MeSH
- chlorid sodný MeSH
- hypertenze * MeSH
- krysa rodu Rattus MeSH
- kuchyňská sůl * MeSH
- potkani inbrední Dahl MeSH
- sympatický nervový systém MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- komentáře MeSH
- úvodníky MeSH
- Názvy látek
- chlorid sodný MeSH
- kuchyňská sůl * MeSH
The important participation of sympathetic nervous system in various forms of experimental hypertension is well known. This is also true for salt hypertension elicited by excess salt intake in Dahl salt-sensitive rats (for review see Zicha et al. 2012). Two recent studies in Dahl rats (Zicha et al. 2019, Puleo et al. 2020) evaluated the hypothesis on the role of beta-adrenergic WNK4-NCC pathway in salt-sensitive hypertension which has been proposed by Mu et al. (2011). Although these studies differed in many experimental details, both of them demonstrated a major importance of alpha1- rather than beta-adrenergic mechanisms for the development of salt hypertension in this rat strain.
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