Contemporary patterns of presentation, diagnostics and management of upper tract urothelial cancer in 101 centres: the Clinical Research Office of the Endourological Society Global upper tract urothelial carcinoma registry
Language English Country United States Media print
Document type Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't
PubMed
34009177
DOI
10.1097/mou.0000000000000899
PII: 00042307-202107000-00011
Knihovny.cz E-resources
- MeSH
- Carcinoma, Transitional Cell * diagnostic imaging epidemiology MeSH
- Humans MeSH
- Kidney Neoplasms * surgery MeSH
- Ureteral Neoplasms * diagnostic imaging epidemiology MeSH
- Nephroureterectomy MeSH
- Registries MeSH
- Ureteroscopy MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Research Support, Non-U.S. Gov't MeSH
PURPOSE OF REVIEW: To assess patterns of presentation, diagnostics and treatment in patients with upper tract urothelial carcinoma (UTUC), a multicentre registry was launched. Clinical data of UTUC patients were prospectively collected over a 5-year period. RECENT FINDINGS: Data from 2380 patients were included from 2014 to 2019 (101 centres in 29 countries). Patients were predominantly male (70.5%) and 53.3% were past or present smokers. The majority of patients (58.1%) were evaluated because of symptoms, mainly macroscopic hematuria. Computed tomography (CT) was the most common performed imaging modality (90.5%). A ureteroscopy (URS) was part of the diagnostic process in 1184 (49.7%) patients and 488 (20.5%) patients were treated endoscopically. In total, 1430 patients (60.1%) were treated by a radical nephroureterectomy, 59% without a prior diagnostic URS. Eighty-two patients (3.4%) underwent a segmental resection, 19 patients (0.8%) were treated by a percutaneous tumour resection. SUMMARY: Our data is in line with the known epidemiologic characteristics of UTUC. CT imaging is the preferred imaging modality as also recommended by guidelines. Diagnostic URS gained a stronger position, however, in almost half of patients a definitive treatment decision was made without complete endoscopic information. Only one-third of patients with UTUC are currently treated with kidney sparing surgery.
Department of Urology 1 M Sechenov University Moscow Russia
Department of Urology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands
Department of Urology Centro Hospitalar Universitário do Porto Porto Portugal
Department of Urology Hospital Clinic i Provincial de Barcelona Barcelona Spain
Department of Urology Medical University of Vienna Vienna Austria
Department of Urology Medipol Mega University Hospital Istanbul Medipol University Istanbul Turkey
Department of Urology Motol Hospital Charles University Praque Czech Republic
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ClinicalTrials.gov
NCT02281188
