Background: Mind-body medicine (MBM) focuses on improving our understanding of how the interactions between the brain, mind, body, and behavior can be used to promote health. In this narrative review, we present the basic principles of MBM, including the introduction of a rational framework for the implementation of MBM-based interventions. We also discuss the contributions of MBM to motivation and reward systems in the brain including those that may specifically involve the mitochondria. Results: MBM can be used to promote health in patients with chronic diseases, especially conditions identified as lifestyle-related. MBM builds on salutogenesis, which is a paradigm that focuses on health (as opposed to disease) determinants and the development of individual resilience and coherence factors as a means to reduce stress, decrease the burden of disease, and improve the quality of life. This approach involves several well-known principles of self-healing and self-care. MBM interventions typically include behavioral modification techniques in conjunction with cognitive work focused on stress regulation, exercise, relaxation, meditation, and nutrition. We suggest the use of the acronym "BERN" (Behavior, Exercise, Relaxation, and Nutrition) to summarize the operational framework of this approach. Discussion: Different BERN techniques act via shared autoregulatory central nervous system (CNS) reward and motivation circuitries. These systems rely on numerous neurobiological signaling pathways with overlapping effector molecules that converge, e.g., on nitric oxide (NO) as a common effector molecule. NO is critically coupled to reward physiology, stress reduction, and self-regulation as it modulates the responses of various mitochondrial, nuclear, and chromosomal processes within brain cells. NO has also been implicated in relevant outcomes (e.g., the placebo response). Conclusions: MBM interventions typically follow the BERN model and aim to strengthen health and resilience, and reduce stress. The mechanisms of action of these processes involve the CNS reward systems and correlate with placebo and self-healing pathways.

Center for Cognitive and Molecular Neuroscience 1st Faculty of Medicine Charles University Prague Czechia

Institute for Integrative Health Care and Health Promotion School of Medicine Witten Herdecke University Witten Germany

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Anderson J. G., Taylor A. G. (2011). The metabolic syndrome and mind-body therapies: a systematic review. J. Nutr. Metab. 2011:276419. 10.1155/2011/276419 PubMed DOI PMC

Antonovsky A. (1979). Health, Stress and Coping. San Francisco: Jossey-Bass.

Antonovsky A. (1996). The salutogenic model as a theory to guide health promotion. Health Promot. Int. 11, 11–18.

Astin J. A., Shapiro S. L., Eisenberg D. M., Forys K. L. (2003). Mind-body medicine: state of the science, implications for practice. J. Am. Board Fam. Pract. 16, 131–147. 10.3122/jabfm.16.2.131 PubMed DOI

Benson H. (1987). Your Maxiumum Mind. New York: Random House.

Benson H., Klipper M. Z. (2000). The Relaxation Response. New York: Harper-Collins.

Bolier L., Haverman M., Westerhof G. J., Riper H., Smit F., Bohlmeijer E., et al. . (2013). Positive psychology interventions: a meta-analysis of randomized controlled studies. BMC Public Health 13:119. 10.1186/1471-2458-13-119 PubMed DOI PMC

Brinkhaus B., Esch T. (2021). Integrative Medizin und Gesundheit. Berlin: Medizinisch Wissenschaftliche Verlagsgesellschaft.

Büttiker P., Weissenberger S., Stefano G. B., Kream R. M., Ptacek R. (2021). SARS-CoV-2, trait anxiety and the microbiome. Front. Psychiatry 12:720082. 10.3389/fpsyt.2021.720082 PubMed DOI PMC

Cannon W. B. (1933). The first American laboratory of physiology. Science 78, 365–366. 10.1126/science.78.2025.365-a PubMed DOI

Casas R., Castro-Barquero S., Estruch R., Sacanella E. (2018). Nutrition and cardiovascular health. Int. J. Mol. Sci. 19:3988. 10.3390/ijms19123988 PubMed DOI PMC

Chakhssi F., Kraiss J. T., Sommers-Spijkerman M., Bohlmeijer E. T. (2018). The effect of positive psychology interventions on well-being and distress in clinical samples with psychiatric or somatic disorders: a systematic review and meta-analysis. BMC Psychiatry 18:211. 10.1186/s12888-018-1739-2 PubMed DOI PMC

Chomistek A. K., Chiuve S. E., Eliassen A. H., Mukamal K. J., Willett W. C., Rimm E. B., et al. . (2015). Healthy lifestyle in the primordial prevention of cardiovascular disease among young women. J. Am. Coll. Cardiol. 65, 43–5110.1016/j.jacc.2014.10.024 PubMed DOI PMC

Cramer H., Lauche R., Klose P., Lange S., Langhorst J., Dobos G. J., et al. . (2017). Yoga for improving health-related quality of life, mental health and cancer-related symptoms in women diagnosed with breast cancer. Cochrane Database Syst. Rev. 1:CD010802. 10.1002/14651858.CD010802.pub2 PubMed DOI PMC

Cramer H., Lauche R., Paul A., Langhorst J., Michalsen A., Dobos G., et al. . (2015). Mind-body medicine in the secondary prevention of coronary heart disease. Dtsch. Arztebl. Int. 112, 759–767. 10.3238/arztebl.2015.0759 PubMed DOI PMC

Dobos G., Altner N., Lange S., Musial F., Langhorst J., Michalsen A., et al. . (2006). Mind-body medicine as a part of German integrative medicine. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 49, 723–728. 10.1007/s00103-006-0001-0 PubMed DOI

Dobos G., Paul A. (2019). Mind-Body-Medizin. München: Elsevier.

Dusek J. A., Otu H. H., Wohlhueter A. L., Bhasin M., Zerbini L. F., Joseph M. G., et al. . (2008). Genomic counter-stress changes induced by the relaxation response. PLoS One 3:e2576. 10.1371/journal.pone.0002576 PubMed DOI PMC

Esch T. (2002). Health in stress: change in the stress concept and its significance for prevention, health and life style. Gesundheitswesen 64, 73–81. 10.1055/s-2002-20275 PubMed DOI

Esch T. (2003). Stress, adaptation and self-organization: balancing processes facilitate health and survival. Forsch. Komplementarmed. Klass. Naturheilkd. 10, 330–341. 10.1159/000075887 PubMed DOI

Esch T. (2008). Mind-body medicine: Stress, stress management and health promotion. Komplement. Integr. Med. 49, 35–39. 10.1016/j.kim.2007.10.002 DOI

Esch T. (2013). “The neurobiology of meditation and mindfulness,” in Meditation - Neuroscientific Approaches and Philosophical Implications, Springer Series: Studies in Neuroscience, Consciousness and Spirituality, Vol. 2, eds Schmidt S., Walach H. (New York: Springer International Publishing; ), 153–173.

Esch T. (2014). Self-regulation: self-healing as part of medicine. Dtsch. Arztebl. 111, A2214–A2220.

Esch T. (2017). The Neurobiology of Happiness. Stuttgart: Academic Press.

Esch T. (2020). Self-healing in health-care: using the example of mind-body medicine. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 63, 577–585. 10.1007/s00103-020-03133-8 PubMed DOI

Esch T. (2021a). Integrating opennotes and promoting self-management in primary care in Germany: the witten model. BMJ online. Available online at: https://blogs.bmj.com/bmj/2021/04/01/tobias-esch-integrating-opennotes-and-promoting-self-management-in-primary-care-in-germany-the-witten-model. Accessed March 26, 2022.

Esch T. (2021b). Meditation in complementary and integrative medicine: taxonomy of effects and methods. Complement. Med. Res. 28, 183–187. 10.1159/000516849 PubMed DOI

Esch T. (2022). The ABC model of happiness - neurobiological aspects of motivation and positive mood and their dynamic changes through practice, the course of life. Biology 11:843. 10.3390/biology11060843 PubMed DOI PMC

Esch T., Brinkhaus B. (2021). “The significance of self-regulation in integrative and mind-body medicine: an overview,” in Integrative Medicine and Health, eds Brinkhaus B., Esch T. (Berlin: Medizinisch Wissenschaftliche Verlagsgesellschaft; ), 17–32.

Esch T., Esch S. M. (2021). Stress Management: Mind-Body Medicine, Mindfulness, Resilience. Berlin: Medizinisch Wissenschaftliche Verlagsgesellschaft.

Esch T., Stefano G. B. (2004). The neurobiology of pleasure, reward processes, addiction and their health implications. Neuro Endocrinol. Lett. 25, 235–251. PubMed

Esch T., Stefano G. B. (2010). The neurobiology of stress management. Neuro Endocrinol. Lett. 31, 19–39. PubMed

Esch T., Fricchione G. L., Stefano G. B. (2003). The therapeutic use of the relaxation response in stress-related diseases. Med. Sci. Monit. 9, RA23–RA34. PubMed

Esch T., Guarna M., Bianchi E., Zhu W., Stefano G. B. (2004). Commonalities in the central nervous system’s involvement with complementary medical therapies: Limbic morphinergic processes. Med. Sci. Monit. 10, MS6–MS17. PubMed

Esch T., Kream R. M., Stefano G. B. (2018). Chromosomal processes in mind-body medicine: chronic stress, cell aging and telomere length. Med. Sci. Monit. Basic Res. 24, 134–140. 10.12659/MSMBR.911786 PubMed DOI PMC

Esch T., Kream R. M., Stefano G. B. (2020a). Emerging regulatory roles of opioid peptides, endogenous morphine and opioid receptor subtypes in immunomodulatory processes: metabolic, behavioral and evolutionary perspectives. Immunol. Lett. 227, 28–33. 10.1016/j.imlet.2020.08.007 PubMed DOI

Esch T., Stefano G. B., Ptacek R., Kream R. M. (2020b). Emerging roles of blood-borne intact and respiring mitochondria as bidirectional mediators of pro- and anti-inflammatory processes. Med. Sci. Monit. 26:e924337. 10.12659/MSM.924337 PubMed DOI PMC

Esch T., Stefano G. B., Fricchione G. L., Benson H. (2002). The role of stress in neurodegenerative diseases and mental disorders. Neuro Endocrinol. Lett. 23, 199–208. PubMed

Esch T., Winkler J., Auwärter V., Gnann H., Huber R., Schmidt S., et al. . (2017). Neurobiological aspects of mindfulness in pain autoregulation: unexpected results from a randomized-controlled trial and possible implications for meditation research. Front. Hum. Neurosci. 10:674. 10.3389/fnhum.2016.00674 PubMed DOI PMC

Fava G. A., Sonino N. (2010). Psychosomatic medicine. Int. J. Clin. Pract. 64, 1155–1161. 10.1111/j.1742-1241.2009.02266.x PubMed DOI

Fiuza-Luces C., Santos-Lozano A., Joyner M., Carrera-Bastos P., Picazo O., Zugaza J. L., et al. . (2018). Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors. Nat. Rev. Cardiol. 15, 731–743. 10.1038/s41569-018-0065-1 PubMed DOI

Flynn N. (2018). Systematic review of the effectiveness of hypnosis for the management of headache. Int. J. Clin. Exp. Hypn. 66, 343–352. 10.1080/00207144.2018.1494432 PubMed DOI

Fricchione G., Stefano G. B. (2005). Placebo neural systems: nitric oxide, morphine and the dopamine brain reward and motivation circuitries. Med. Sci. Monit. 11, MS54–MS65. PubMed

Gothe N. P., Khan I., Hayes J., Erlenbach E., Damoiseaux J. S. (2019). Yoga effects on brain health: a systematic review of the current literature. Brain Plast. 5, 105–122. 10.3233/BPL-190084 PubMed DOI PMC

Goyal M., Singh S., Sibinga E. M., Gould N. F., Rowland-Seymour A., Sharma R., et al. . (2014). Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA Intern. Med. 174, 357–368. 10.1001/jamainternmed.2013.13018 PubMed DOI PMC

Hall K. T., Lembo A. J., Kirsch I., Ziogas D. C., Douaiher J., Jensen K. B., et al. . (2012). Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. PLoS One 7:e48135. 10.1371/journal.pone.0048135 PubMed DOI PMC

Hepsomali P., Groeger J. A., Nishihira J., Scholey A. (2020). Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: a systematic review. Front. Neurosci. 14:923. 10.3389/fnins.2020.00923 PubMed DOI PMC

Jeitler M., Jaspers J., von Scheidt C., Koch B., Michalsen A., Steckhan N., et al. . (2017). Mind-body medicine and lifestyle modification in supportive cancer care: a cohort study on a day care clinic program for cancer patients. Psychooncology 26, 2127–2134. 10.1002/pon.4433 PubMed DOI

Joyce S., Shand F., Tighe J., Laurent S. J., Bryant R. A., Harvey S. B., et al. . (2018). Road to resilience: a systematic review and meta-analysis of resilience training programmes and interventions. BMJ Open 8:e017858. 10.1136/bmjopen-2017-017858 PubMed DOI PMC

Kam-Hansen S., Jakubowski M., Kelley J. M., Kirsch I., Hoaglin D. C., Kaptchuk T. J., et al. . (2014). Altered placebo and drug labeling changes the outcome of episodic migraine attacks. Sci. Transl. Med. 6:218ra5. 10.1126/scitranslmed.3006175 PubMed DOI PMC

Kaptchuk T. J., Friedlander E., Kelley J. M., Sanchez M. N., Kokkotou E., Singer J. P., et al. . (2010). Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One 5:e15591. 10.1371/journal.pone.0015591 PubMed DOI PMC

Koch S., Esch T., Werdecker L. (2022). Effects of a yoga-based stress intervention program on the blood pressure of young police officers: a randomized controlled trial. J. Integr. Complement. Med. 28, 234–240. 10.1089/jicm.2021.0294 PubMed DOI

Komaroff A. L. (2001). Mind-Body Medicine: A Special Health Report. Boston: Harvard Health Publications.

Laux G., Kühlein T., Gutscher A., Szecsenyi J. (2010). “Versorgungsforschung in der Hausarztpraxis,” in Ergebnisse aus dem CONTENT-Projekt, (München: Springer; ), 2006–2009.

Lee D., Kang D. H., Ha N. H., Oh C. Y., Lee U., Kang S. W., et al. . (2018). Effects of an online mind-body training program on the default mode network: an eeg functional connectivity study. Sci. Rep. 8:16935. 10.1038/s41598-018-34947-x PubMed DOI PMC

Long J., Briggs M., Astin F. (2017). Overview of systematic reviews of mindfulness meditation-based interventions for people with long-term conditions. Adv. Mind Body Med. 31, 26–36. PubMed

Ludolph P., Kunzler A. M., Stoffers-Winterling J., Helmreich I., Lieb K. (2019). Interventions to promote resilience in cancer patients. Dtsch. Arztebl. Int. 51, 865–872. 10.3238/arztebl.2019.0865 PubMed DOI PMC

Mann E. O., Kohl M. M., Paulsen O. (2009). Distinct roles of GABA(A) and GABA(B) receptors in balancing and terminating persistent cortical activity. J. Neurosci. 29, 7513–7518. 10.1523/JNEUROSCI.6162-08.2009 PubMed DOI PMC

McClafferty H. (2011). Complementary, holistic and integrative medicine: mind-body medicine. Pediatr. Rev. 32, 201–203. 10.1542/pir.32-5-201 PubMed DOI

McEwen B. S. (1998). Stress, adaptation and disease: allostasis and allostatic load. Ann. N Y Acad. Sci. 840, 33–44. 10.1111/j.1749-6632.1998.tb09546.x PubMed DOI

Michaelsen M. M., Esch T. (2021). Motivation and reward mechanisms in health behavior change processes. Brain Res. 1757:147309. 10.1016/j.brainres.2021.147309 PubMed DOI

Michaelsen M. M., Esch T. (2022). Functional mechanisms of health behavior change techniques: a conceptual review. Front. Psychol. 13:725644. 10.3389/fpsyg.2022.725644 PubMed DOI PMC

Michaelsen M. M., Graser J., Onescheit M., Tuma M., Pieper D., Werdecker L., et al. . (2021). iga.Report 45: Effectiveness of Mindfulness Techniques in the Work Context. Berlin: Initiative Gesundheit und Arbeit.

Michalsen A., Grossman P., Acil A., Langhorst J., Lüdtke R., Esch T., et al. . (2005). Rapid stress reduction and anxiolysis among distressed women as a consequence of a three-month intensive yoga program. Med. Sci. Monit. 11, CR555–CR561. PubMed

Miko H. C., Zillmann N., Ring-Dimitriou S., Dorner T. E., Titze S., Bauer R., et al. . (2020). Effects of physical activity on health. Gesundheitswesen 82, 184–195. 10.1055/a-1217-0549 PubMed DOI PMC

Moss A. S., Reibel D. K., Wintering N., Vedaei F., Porter H., Khosravi M., et al. . (2022). Cerebral blood flow and brain functional connectivity changes in older adults participating in a mindfulness-based stress reduction program. Behav. Sci. (Basel) 12:48. 10.3390/bs12020048 PubMed DOI PMC

Namgung E., Kim J., Jeong H., Ma J., Hong G., Kang I., et al. . (2021). Changes in prefrontal gamma-aminobutyric acid and perfusion after the computerized relaxation training in women with psychological distress: a preliminary report. Front. Psychol. 12:569113. 10.3389/fpsyg.2021.569113 PubMed DOI PMC

National Center for Complementary and Integrative Health (NCCIH), National Institutes of Health (NIH), U.S. Department of Health and Human Services (2019). Mind-Body Medicine. Available online at: https://nccih.nih.gov/video/series/mindbody. Accessed September 25, 2019.

National Institutes of Health (NIH), U.S. Department of Health and Human Services (2019). Fact Sheets. Available online at: https://report.nih.gov/nihfactsheets/viewfactsheet.aspx?csid=102. Accessed September 25, 2019.

Naude C. E., Durao S., Harper A., Volmink J. (2017). Scope and quality of cochrane reviews of nutrition interventions: a cross-sectional study. Nutr. J. 16:22. 10.1186/s12937-017-0244-7 PubMed DOI PMC

Nitschke E., Gottesman K., Hamlett P., Mattar L., Robinson J., Tovar A., et al. . (2022). Impact of nutrition and physical activity interventions provided by nutrition and exercise practitioners for the adult general population: a systematic review and meta-analysis. Nutrients 14:1729. 10.3390/nu14091729 PubMed DOI PMC

Ospina M. B., Bond K., Karkhaneh M., Tjosvold L., Vandermeer B., Liang Y., et al. . (2007). Meditation practices for health: state of the research. Evid. Rep. Technol. Assess. 155, 1–263. PubMed PMC

Park E. R., Luberto C. M., Chad-Friedman E., Traeger L., Hall D. L., Perez G. K., et al. . (2021). A comprehensive resiliency framework: theoretical model, treatment and evaluation. Glob. Adv. Health Med. 10:21649561211000306. 10.1177/21649561211000306 PubMed DOI PMC

Pascoe M. C., Thompson D. R., Ski C. F. (2017). Yoga, mindfulness-based stress reduction and stress-related physiological measures: a meta-analysis. Psychoneuroendocrinology 86, 152–168. 10.1016/j.psyneuen.2017.08.008 PubMed DOI

Paul A., Altner N. (2019). “Grundlagen der mind-body-medizin: historische entwicklung und moderne perspektiven,“ in Mind-Body-Medizin, eds Dobos G., Paul A. (München: Elsevier; ), 5–13.

Posadzki P., Cramer H., Kuzdzal A., Lee M. S., Ernst E. (2014). Yoga for hypertension: a systematic review of randomized clinical trials. Complement. Ther. Med. 22, 511–522. 10.1016/j.ctim.2014.03.009 PubMed DOI

Posadzki P., Pieper D., Bajpai R., Makaruk H., Könsgen N., Neuhaus A. L., et al. . (2020). Exercise/physical activity and health outcomes: an overview of cochrane systematic reviews. BMC Public Health 20:1724. 10.1186/s12889-020-09855-3 PubMed DOI PMC

Prochaska J. J., Prochaska J. O. (2011). A review of multiple health behavior change interventions for primary prevention. Am. J. Lifestyle Med. 5, 208–221. 10.1177/1559827610391883 PubMed DOI PMC

Rees K., Dyakova M., Wilson N., Ward K., Thorogood M., Brunner E., et al. . (2013). Dietary advice for reducing cardiovascular risk. Cochrane Database of Syst. Rev. 12:CD002128. 10.1002/14651858.CD002128.pub5 PubMed DOI PMC

Rozanski A., Bavishi C., Kubzansky L. D., Cohen R. (2019). Association of optimism with cardiovascular events and all-cause mortality: a systematic review and meta-analysis. JAMA Netw. Open 2:e1912200. 10.1001/jamanetworkopen.2019.12200 PubMed DOI PMC

Salamon E., Esch T., Stefano G. B. (2006). Pain and relaxation. Int. J. Mol. Med. 18, 465–470.10.3892/ijmm.18.3.465 PubMed DOI

Seligman M. E. P., Csikszentmihalyi M. (2000). Positive psychology: an introduction. Am. Psychol. 55, 5–14. 10.1037//0003-066x.55.1.5 PubMed DOI

Sezer I., Pizzagalli D. A., Sacchet M. D. (2022). Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: a review and synthesis. Neurosci. Biobehav. Rev. 135:104583. 10.1016/j.neubiorev.2022.104583 PubMed DOI PMC

Shin S. (2021). Meta-analysis of the effect of yoga practice on physical fitness in the elderly. Int. J. Environ. Res. Public Health 18:11663. 10.3390/ijerph182111663 PubMed DOI PMC

Siegel R. D. (2009). Positive Psychology: A Special Health Report. Boston: Harvard Health Publications.

Sobel D. (2000). Mind matters, money matters: the cost-effectiveness of mind/body medicine. JAMA 284:1705. 10.1001/jama.284.13.1705-JMS1004-3-1 PubMed DOI

Stahl J. E., Dossett M. L., LaJoie A. S., Denninger J. W., Mehta D. H., Goldman R., et al. . (2015). Relaxation response and resiliency training and its effect on healthcare resource utilization. PLoS One 10:e0140212. 10.1371/journal.pone.0140212 PubMed DOI PMC

Stefano G. B., Esch T. (2005). Integrative medical therapy: examination of meditation’s therapeutic and global medicinal outcomes via nitric oxide (review). Int. J. Mol. Med. 16, 621–630. 10.3892/ijmm.16.4.621 PubMed DOI

Stefano G. B., Benson H., Fricchione G. L., Esch T. (2005). The Stress Response: Always Good and When It Is Bad. New York: Medical Science International.

Stefano G. B., Esch T., Kream R. M. (2019a). Augmentation of whole-body metabolic status by mind-body training: synchronous integration of tissue- and organ-specific mitochondrial function. Med. Sci. Monit. Basic Res. 25, 8–14. 10.12659/MSMBR.913264 PubMed DOI PMC

Stefano G. B., Esch T., Kream R. M. (2019b). Behaviorally-mediated entrainment of whole-body metabolic processes: conservation and evolutionary development of mitochondrial respiratory complexes. Med. Sci. Monit. 25, 9306–9309. 10.12659/MSM.920174 PubMed DOI PMC

Stefano G. B., Fricchione G. L., Esch T. (2006). Relaxation: molecular and physiological significance. Med. Sci. Monit. 12, HY21–HY31. PubMed

Stefano G. B., Fricchione G. L., Slingsby B. T., Benson H. (2001). The placebo effect and relaxation response: neural processes and their coupling to constitutive nitric oxide. Brain Res. Rev. 35, 1–19. 10.1016/s0165-0173(00)00047-3 PubMed DOI

Tjen-A-Looi S. C., Guo Z. L., Longhurst J. C. (2014). GABA in nucleus tractus solitarius participates in electroacupuncture modulation of cardiopulmonary bradycardia reflex. Am. J. Physiol. Regul. Integr. Comp. Physiol. 307, R1313–R1323. 10.1152/ajpregu.00300.2014 PubMed DOI PMC

van der Eijk P. (2011). History of medicine: health - personal responsibility or destiny? Dtsch. Arztebl. 108:A2330.

Voiss P., Höxtermann M. D., Dobos G., Cramer H. (2019). Cancer, sleep problems and mind-body medicine use: results of the 2017 national health interview survey. Cancer 125, 4490–4497. 10.1002/cncr.32469 PubMed DOI

Werdecker L., Esch T. (2021). “Bedeutung und Rolle von Gesundheitsberufen in der Prävention und Gesundheitsförderung,” in Prävention und Gesundheitsförderung, eds Tiemann M., Mohokum M. (Berlin : Springer Nature; ), 159–170.

Wibowo R. A., Nurámalia R., Nurrahma H. A., Oktariani E., Setiawan J., Icanervilia A. V., et al. . (2022). The effect of yoga on health-related fitness among patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Int. J. Environ. Res. Public Health 19:4199. 10.3390/ijerph19074199 PubMed DOI PMC

Wolever R. Q., Bobinet K. J., McCabe K., Mackenzie E. R., Fekete E., Kusnick C. A., et al. . (2012). Effective and viable mind-body stress reduction in the workplace: a randomized controlled trial. J. Occup. Health Psychol. 17, 246–258. 10.1037/a0027278 PubMed DOI

Zhang X., Zong B., Zhao W., Li L. (2021). Effects of mind-body exercise on brain structure and function: a systematic review on MRI studies. Brain Sci. 11:205. 10.3390/brainsci11020205 PubMed DOI PMC