Stress affects cellular aging and inflammatory and chromosomal processes, including telomere length, thereby potentially compromising health and facilitating disease onset and progression. Stress-related diseases and strategies to manage stress usually require integrative or behavioral therapeutic approaches that also operate on cellular levels. Mind-body medicine (MBM) uses the interaction between the mind, body, behavior, and the environment to correct physical and psychological malfunctions, thus ameliorating disease states and improving health. The relaxation response (RR) is a physiological opponent of stress and the stress response (SR) (i.e., fight-or-flight response), also invoking molecular anti-stress processes. Techniques that elicit the RR are at the core of practically all MBM interventions. We surmise that these techniques can also affect chromosomal and telomere processes, molecular aging, and the modulation of inflammatory states on cellular levels.

Department of Psychiatry 1st Faculty of Medicine Charles University Prague and General University Hospital Prague Center for Cognitive and Molecular Neuroscience Prague Czech Republic

School of Medicine Faculty of Health Witten Herdecke University Institute for Integrative Health Care Witten Germany

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Esch T. Health in stress: Change in the stress concept and its significance for prevention, health and life style. Gesundheitswesen. 2002;64(2):73–81. PubMed

Esch T, Stefano GB. The neurobiology of stress management. Neuro Endocrinol Lett. 2010;31(1):19–39. PubMed

Werdecker L, Esch T. Stress and health. In: Haring R, editor. Health Sciences. Heidelberg: Springer; 2018. [in press]

Stefano GB, Cadet P, Zhu W, et al. The blueprint for stress can be found in invertebrates. Neuro Endocrinol Lett. 2002;23:85–93. PubMed

Epel ES, Blackburn EH, Lin J, et al. Accelerated telomere shortening in response to life stress. Proc Nati Acad Sci USA. 2004;101(49):17312–15. PubMed PMC

Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature. 1990;345(6274):458–60. PubMed

Blackburn EH, Epel ES, Lin J. Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. Science. 2015;350(6265):1193–98. PubMed

Puterman E, Lin J, Krauss J, et al. Determinants of telomere attrition over 1 year in healthy older women. Stress and health behaviors matter. Mol Psychiatry. 2015;20(4):529–35. PubMed PMC

Jacobs JJL. Loss of telomere protection: Consequences and opportunities. Front Oncol. 2013;3:88. PubMed PMC

Mathur MB, Epel E, Kind S, et al. Perceived stress and telomere length: A systematic review, meta-analysis, and methodologic considerations for advancing the field. Brain Behav Immun. 2016;54:158–69. PubMed PMC

Stefano GB, Benson H, Fricchione GL, Esch T. The stress response: Always good and when it is bad. Med Sci; New York: 2005.

Epel E, Daubenmier J, Moskowitz JT, et al. Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres. Ann NY Acad Sci. 2009;1172:34–53. PubMed PMC

Trajano LADSN, Trajano ETL, Silva MADS, et al. Genomic stability and telomere regulation in skeletal muscle tissue. Biomed Pharmacother. 2018;98:907–15. PubMed

Esch T, Stefano GB, Fricchione GL, Benson H. The role of stress in neurodegenerative diseases and mental disorders. Neuroendocrinol Lett. 2002;23(3):199–208. PubMed

Esch T, Stefano GB. Proinflammation: A common denominator or initiator of different pathophysiological disease processes. Med Sci Monit. 2002;8(5):HY1–9. PubMed

Armanios M, Blackburn EH. The telomere syndromes. Nat Rev Genet. 2012;13(10):693–704. PubMed PMC

Romano GH, Harari Y, Yehuda T, et al. Environmental stresses disrupt telomere length homeostasis. PLoS Genet. 2013;9(9) e1003721. PubMed PMC

Wang Y, Zhao Z, Zhu Z, et al. Telomere elongation protects heart and lung tissue cells from fatal damage in rats exposed to severe hypoxia. J Physiol Anthropol. 2018;37(1):5. PubMed PMC

Black DS, Cole St W, Irwin MR, et al. Yogic meditation reverses NF-kappaB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial. Psychoneuroendocrinology. 2013;38(3):348–55. PubMed PMC

Bhasin MK, Dusek JA, Chang B-H, et al. Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS One. 2013;8(5) e62817. PubMed PMC

Denninger J, Bhasin MK, Corrigan AA, et al. Functional genomics in the study of mind-body therapies. Ochsner J. 2014;(14):681–95. PubMed PMC

Ornish D, Lin J, Chan JM, et al. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer. 5-year follow-up of a descriptive pilot study. Lancet Oncol. 2013;14(11):1112–20. PubMed

Goglin SE, Farzaneh-Far R, Epel ES, et al. Change in leukocyte telomere length predicts mortality in patients with stable coronary heart disease from the heart and soul study. PLoS One. 2016;11(10) e0160748. PubMed PMC

Benson H. The relaxation response. William Morrow; New York: 1975.

Cole SW. Human social genomics. PLoS Genet. 2014;10(8) e1004601. PubMed PMC

Buric I, Farias M, Jong J, et al. What is the molecular signature of mind-body interventions? A systematic review of gene expression changes induced by meditation and related practices. Front Immunol. 2017;8:670. PubMed PMC

Benz D, Cadet P, Mantione K, et al. Tonal nitric oxide and health: A free radical and a scavenger of free radicals. Med Sci Monit. 2002;8(1):RA1–4. PubMed

Stefano GB, Scharrer B. Endogenous morphine and related opiates, a new class of chemical messengers. Adv Neuroimmunol. 1994;4:57–68. PubMed

Esch T, Mantione KJ, Stefano GB. Stress, proinflammation, autoregulation, and cardiovascular diseases. Brain Immune. 2011. Available from: http://www.brainimmune.com/stress-proinflammation-autoregulation-and-cardiovascular-diseases/

Slavich GM. Understanding inflammation, its regulation, and relevance for health. A top scientific and public priority. Brain Behav and Immun. 2015;45:13–14. PubMed PMC

Kearney DJ, Brown-Chang J. Complementary and alternative medicine for IBS in adults. Mind-body interventions. Nat Clin Pract Gastroenterol Hepatol. 2008;5(11):624–36. PubMed

Esch T, Stefano GB, Fricchione GL. The therapeutic use of the relaxation response in stress-related diseases. Med Sci Monit. 2003;9(2):RA23–34. PubMed

Dusek JA, Otu HH, Wohlhueter AL, et al. Genomic counter-stress changes induced by the relaxation response. PLoS One. 2008;3(7) e2576. PubMed PMC

Esch T, von Bernus L. In: Dobos G, Paul A, editors. [Mind-Body-Medizin]. Munich: Elsevier; 2018. [in press]

Bhasin M, Fan X, Libermann T, et al. Epigenetic alterations associated with short-term relaxation response training in healthy subjects. Presentation and Abstract, World Congress of Integrative Medicine; 2017 May 3–5; Berlin.

Fyfe-Johnson A, Taylor D, Zierold C, Dusek J. Effects of relaxation response intervention on endogenous progenitor cells in a hypertensive population. BMC Complement Altern Med. 2012;12(Suppl 1):O13.

Welters ID, Fimiani C, Bilfinger TV, Stefano GB. NF-κB, nitric oxide and opiate signaling. Medical Hypotheses. 1999;54:263–68. PubMed

Kuo B, Bhasin M, Jacquart J, et al. Genomic and clinical effects associated with a relaxation response mind-body intervention in patients with irritable bowel syndrome and inflammatory bowel disease. PLoS One. 2015;10(4) e0123861. PubMed PMC

Stefano GB, Esch T, Bilfinger TV, Kream RM. Proinflammation and preconditioning protection are part of a common nitric oxide mediated process. Med Sci Monit. 2010;16(6):125–30. PubMed

Creswell JD, Irwin MR, Burklund LJ, et al. Mindfulness-based stress reduction training reduces loneliness and pro-inflammatory gene expression in older adults. A small randomized controlled trial. Brain Behav Immun. 2012;26(7):1095–101. PubMed PMC

Stefano GB, Goumon Y, Bilfinger TV, et al. Basal nitric oxide limits immune, nervous and cardiovascular excitation: Human endothelia express a mu opiate receptor. Prog Neurobiol. 2000;60:513–30. PubMed

Stefano GB, Esch T. Integrative medical therapy: Examination of meditation‘s therapeutic and global medicinal outcomes via nitric oxide. Int J Mol Med. 2005;16:621–30. PubMed

Cahn BR, Goodman MS, Peterson CT, et al. Meditation and mind-body health. Increased BDNF, cortisol awakening response, and altered inflammatory marker expression after a 3-month yoga and meditation retreat. Front Hum Neurosci. 2017;11:315. PubMed PMC

Manchanda SC, Madan K. Yoga and meditation in cardiovascular disease. Clin Res Cardiol. 2014;103(9):675–80. PubMed

Stefano GB, Kream RM. Alkaloids, nitric oxide, and nitrite reductases: Evolutionary coupling as key regulators of cellular bioenergetics with special relevance to the human microbiome. Med Sci Monit. 2018;24:3153–58. PubMed PMC

Stefano GB, Mantione KJ, Capellan L, et al. Morphine stimulates nitric oxide release in human mitochondria. J Bioenerget Biomembr. 2015;47(5):409–17. PubMed

Stefano GB, Mantione KJ, Casares FM, Kream RM. Anaerobically functioning mitochondria: Evolutionary perspective on modulation of energy metabolism in Mytilus edulis. Invertebr Surv J. 2015;12:22–28.

Sun N, Youle RJ, Finkel T. The mitochondrial basis of aging. Mol Cell. 2016;61(5):654–66. PubMed PMC

Stefano GB, Pilonis N, Ptacek R, et al. Gut, microbiome, and brain regulatory axis: Relevance to neurodegenerative and psychiatric disorders. Cell Mol Neurobiol. 2018;38(6):1197–206. PubMed PMC

Esch T, Stefano GB. The neurobiology of pleasure, reward processes, addiction and their health implications. Neuroendocrinol Lett. 2004;25(4):235–51. PubMed

Esch T. The Neurobiology of meditation and mindfulness. In: Schmidt S, Walach H, editors. Meditation – neuroscientific approaches and philosophical implications. Vol. 2. Springer International Publishing; New York: 2014. pp. 153–73. (Springer Series: Studies in Neuroscience, Consciousness and Spirituality).

Rothschild D, Weissbrod O, Barkan E, et al. Environment dominates over host genetics in shaping human gut microbiota. Nature. 2018;555(7695):210–15. PubMed

Thaiss CA, Levy M, Korem T, et al. Microbiota diurnal rhythmicity programs host transcriptome oscillations. Cell. 2016;167(6):1495–510. PubMed

Maier L, Pruteanu M, Kuhn M, et al. Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018;555(7698):623–28. PubMed PMC

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