Essential oil components (EOCs) such as eugenol play a significant role in plant antimicrobial defense. Due to the volatility and general reactivity of these molecules, plants have evolved smart systems for their storage and release, which are key prerequisites for their efficient use. In this study, biomimetic systems for the controlled release of eugenol, inspired by natural plant defense mechanisms, were prepared and their antifungal activity is described. Delivery and antifungal studies of mesoporous silica nanoparticles (MSN) loaded with eugenol and capped with different saccharide gates-starch, maltodextrin, maltose and glucose-against fungus Aspergillus niger-were performed. The maltodextrin- and maltose-capped systems show very low eugenol release in the absence of the fungus Aspergillus niger but high cargo delivery in its presence. The anchored saccharides are degraded by exogenous enzymes, resulting in eugenol release and efficient inhibition of fungal growth.

CIBER de Bioingeniería Biomateriales y Nanomedicina Av Monforte de Lemos 3 5 Pabellón 11 Planta 0 28029 Madrid Spain

Department of Food Science Faculty of Agrobiology Food and Natural Resources Czech University of Life Sciences Prague Kamýcká 129 16500 Praha Suchdol Czech Republic

Department of Food Technology Universitat Politècnica de València Camino de Vera s n 46022 Valencia Spain

Department of Inorganic Technology Faculty of Chemical Technology University of Chemistry and Technology Prague Technická 5 Praha 6 16628 Prague Czech Republic

Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico Universitat Politècnica de València Universitat de València Camino de Vera s n 46022 Valencia Spain

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