Antibacterial photodynamic activity of hydrophobic carbon quantum dots and polycaprolactone based nanocomposite processed via both electrospinning and solvent casting method
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
34311091
DOI
10.1016/j.pdpdt.2021.102455
PII: S1572-1000(21)00279-9
Knihovny.cz E-resources
- Keywords
- Antibacterial activity, Carbon quantum dots, Electrospinning, Film casting, Polycaprolactone,
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Photochemotherapy * methods MeSH
- Photosensitizing Agents pharmacology MeSH
- Quantum Dots * MeSH
- Nanocomposites * MeSH
- Polyesters MeSH
- Solvents MeSH
- Carbon MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Photosensitizing Agents MeSH
- polycaprolactone MeSH Browser
- Polyesters MeSH
- Solvents MeSH
- Carbon MeSH
Inhabitation of various types of bacteria on different surfaces causes vital health problems worldwide. In this work, a wound dressing defeating bacterial infection had been fabricated. The antibacterial effect of polycaprolactone and hydrophobic carbon quantum dots (hCQDs) based nanocomposite has been presented. The nanocomposite was fabricated both via solvent casting and electrospinning method. Nanocomposites with and without hCQDs had been investigated. A detailed study on their morphology and surface properties were performed by scanning electron microscopy, atomic force microscopy and Raman spectroscopy. Prepared nanocomposites had been evaluated by the contact angle, UV-Vis spectroscopy, electron paramagnetic resonance spectroscopy, and antibacterial activity. It was found that nanocomposites were able to produce singlet oxygen upon blue light irradiation at 470 nm, and they were effective in the eradication of Gram positive (Staphylococcus aureus, Listeria monocytogenes) and Gram negative (Escherichia coli, Klebsiella pneumoniae) bacteria.
Division of Pharmaceutics Department of Pharmaceutical Technology Jadavpur University Kolkata India
Institute of Physics Slovak Academy of Sciences Dúbravská cesta 9 Bratislava 845 11 Slovakia
Polymer Institute Slovak Academy of Sciences Dubravska cesta 9 Bratislava 845 41 Slovakia
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