Specific protocols define eligibility, conditioning, donor selection, graft composition and prophylaxis of graft vs. host disease for children and young adults undergoing hematopoietic stem cell transplant (HSCT). However, international protocols rarely, if ever, detail supportive care, including pharmaceutical infection prophylaxis, physical protection with face masks and cohort isolation or food restrictions. Supportive care suffers from a lack of scientific evidence and implementation of practices in the transplant centers brings extensive restrictions to the child's and family's daily life after HSCT. Therefore, the Board of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) held a series of dedicated workshops since 2017 with the aim of initiating the production of a set of minimal recommendations. The present paper describes the consensus reached within the field of infection prophylaxis.

Cansearch Research Platform in Paediatric Oncology and Haematology Department of Paediatrics Gynaecology and Obstetrics Faculty of Medicine University of Geneva Geneva Switzerland

Central Hospital of Southern Pest National Institute of Hematology and Infectious Disease Budapest Hungary

Children's Hospital and Pediatric Research Center University of Helsinki Helsinki Finland

Clinica Pediatrica Università degli Studi di Milano Bicocca Fondazione Monza e Brianza per il Bambino e la sua Mamma Ospedale San Gerardo Monza Italy

Department of Bone Marrow Transplantation Great Ormond Street Hospital for Children National Health Service Foundation Trust London United Kingdom

Department of Hematology Immunology Oncology and Stem Cell Transplantation University Children's Hospital Zürich Zurich Switzerland

Department of Paediatric Haematology Oncology Royal Hospital for Children Glasgow United Kingdom

Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet Copenhagen Denmark

Department of Pediatric Bone Marrow Transplantation Unit Medicalpark Göztepe Hospital Istanbul Turkey

Department of Pediatric Hematology and Oncology Hospital Motol Charles University Prague Czechia

Department of Pediatric Hematology and Oncology Oslo University Hospital Oslo Norway

Department of Pediatric Hematology and Pediatric Stem Cell Transplantation Unit Antalya and Göztepe Medicalpark Hospitals Antalya Turkey

Department of Pediatric Hematology Oncology and Bone Marrow Transplantation Wroclaw Medical University Wroclaw Poland

Department of Pediatric Hematology Oncology and Cell and Gene Therapy Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Bambino Gesù Rome Italy

Department of Pediatric Hematology Oncology and Stem Cell Transplantation University Hospital of Regensburg Regensburg Germany

Department of Pediatric Oncology and Hematology Hospital Universitari Vall d'Hebron Barcelona Spain

Department of Pediatric Oncology Hematology and Hematopoietic Stem Cell Transplantation Poznan University of Medical Sciences Poznan Poland

Department of Pediatrics Oulu University Hospital Oulu Finland

Department of Pediatrics University Hospital Center Zagreb Zagreb Croatia

Division for Pediatric Hematology and Oncology Hospital for Children and Adolescents University Hospital Goethe University Frankfurt am Main Germany

Division for Stem Cell Transplantation Immunology and Intensive Care Medicine Hospital for Children and Adolescents University Hospital Goethe University Frankfurt am Main Germany

Division of Molecular Hematology Lund University Lund Sweden

Division of Pediatric Hematology Oncology and Bone Marrow Transplantation The Edmond and Lily Safra Children's Hospital Tel Aviv Israel

Division of Pediatric Hematology Oncology University Children's Hospital of Basel Basel Switzerland

Division of Pediatric Hematology Oncology University Hospital of Geneva Geneva Switzerland

Division of Pediatric Hematoloy Oncology Schneider Children's Medical Center of Israel Petach Tikva Israel

Division of Pediatric Stem Cell Therapy Department of Pediatric Oncology Hematology and Clinical Immunology Medical Faculty Heinrich Heine University Duesseldorf Germany

Division of Stem Cell Transplantation and Regenerative Medicine Department of Pediatrics School of Medicine Stanford University Stanford CA United States

European Society for Blood and Marrow Transplantation Paris Office Hôpital Saint Antoine Paris France

Hematology and Immunology Department Robert Debre Hospital Assistance Publique Hopitaux de Paris and University of Paris Paris France

Institute for Transfusion Medicine and Immunohematology of Goethe University German Red Cross Blood Service Baden Württemberg Hessen Frankfurt am Main Germany

Paediatric Haematology Oncology Department Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini Genova Italy

Paediatric Transplant Unit Hospital University and Polytechnic Hospital LA FE Valencia Spain

Paediatrics and Adolescent Medicine Medical Faculty University of Augsburg Augsburg Germany

Pediatric Hematology Oncology and Hematopoietic Stem Cell Transplantation Unit Hospital Santa Creu i Sant Pau Barcelona Spain

Pediatric Hematology Oncology Department of Mother and Child Azienda Ospedaliera Universitaria Integrata Verona Italy

Stem Cell Transplantation Unit Department of Pediatrics St Anna Children's Hospital Medical University of Vienna Vienna Austria

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