Cytomegalovirus is one of the most important infections to occur after allogeneic haematopoietic stem cell transplantation (HSCT), and an increasing number of reports indicate that cytomegalovirus is also a potentially important pathogen in patients treated with recently introduced drugs for hematological malignancies. Expert recommendations have been produced by the 2017 European Conference on Infections in Leukaemia (ECIL 7) after a review of the literature on the diagnosis and management of cytomegalovirus in patients after HSCT and in patients receiving other types of therapy for haematological malignancies. These recommendations cover diagnosis, preventive strategies such as prophylaxis and pre-emptive therapy, and management of cytomegalovirus disease. Antiviral drugs including maribavir and letermovir are in development and prospective clinical trials have recently been completed. However, management of patients with resistant or refractory cytomegalovirus infection or cytomegalovirus disease is a challenge. In this Review we summarise the reviewed literature and the recommendations of the ECIL 7 for management of cytomegalovirus in patients with haematological malignancies.

Assistance Publique Hopitaux de Paris Department of Hematology Henri Mondor Hospital and Université Paris Est Créteil Créteil France

Department of Cellular Therapy and Allogeneic Stem Cell Transplantation Karolinska University Hospital and Division of Hematology Department of Medicine Karolinska Institutet Stockholm Sweden

Department of Hematology Hospital de la Princesa Madrid Spain

Department of Medical Microbiology and Department of Paediatric Haematology and Oncology 2nd Faculty of Medicine of Motol University Hospital and Charles University Prague Czech Republic

Division of Infection and Immunity University College London London UK

Fred Hutchinson Cancer Research Center Seattle WA USA

Medizinische Klinik und Poliklinik 2 Julius Maximilians Universitaet Würzburg Germany

Microbiology Service Hospital Clínico Universitario Instituto de Investigación INCLIVA Valencia Spain; Department of Microbiology School of Medicine University of Valencia Valencia Spain

Servizio Immunoematologia e Medicina Trasfusionale Azienda Socio Sanitaria Territoriale di Bergamo Ovest Treviglio Italy

Citace poskytuje Crossref.org

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