The current guidelines for prevention of infections in hematopoietic stem cell transplantation (HSCT) do not specify which central venous catheter (CVC) insertion site should be preferred in allogeneic HSCT recipients-internal jugular vein (IJV) or subclavian vein (SCV). We designed a multicenter prospective observational study comparing the risk of infectious and non-infectious complications between the two most common sites of CVC insertion (IJV and SCV) in allogeneic HSCT. There were in total 232 consecutive patients (86 IJV and 146 SCV) who underwent adult allogeneic HSCT reported from 11 centers in 8 countries. The center independent analysis of central line associated/related blood stream infections with ECDC criteria has shown statistically significant difference favoring SCV (23% IJV vs 13% SCV (OR 2.03 (1.01-4.06), p = 0.047)). The differences in CLABSI per 1000 days of CVC use favored SCV over IJV (7.93/1000 days IJV vs 2.79/1000 days SCV, p = 0.002). The frequency of all non-infectious complications was similar in both arms-13% IJV and 12% SCV (OR 1.1 (0.5-2.5), p = 0.8). This multicenter prospective study showed statistically significant lower confirmed number of CLABSI per 1000 days of CVC use without higher risk of noninfectious complications related to the subclavian insertion site in allogeneic HSCT recipients.

Azienda Ospedaliera Universitaria Integrata Verona Verona Italy

Charles University Hospital Pilsen Czech Republic

Collegium Medicum UMK Torun University Hospital Bydgoszcz Poland

Department of Experimental and Clinical Physiology Laboratory of Centre for Preclinical Research Medical University of Warsaw Warsaw Poland

Department of Hematology and Bone Marrow Transplantation Poznan University of Medical Sciences Poznan Poland

Department of Hematology Transplantology and Internal Medicine Central University Hospital Medical University of Warsaw Warsaw Poland

Division of Infectious Diseases Department of Health Sciences University of Genoa Genoa Italy

Division of Infectious Diseases IRCCS Ospedale Policlinico San Martino Genoa Italy

EBMT Data Office Leiden Leiden The Netherlands

Hannover Medical School Hannover Germany

Hospital Santa Creu i Sant Pau Barcelona Spain

Hospital University Marqués de Valdecilla Santander Spain

ICO Hospital Duran i Reynals Barcelona Spain

Maria Sklodowska Curie Institute Gliwice Poland

NHS Christie Tr Manchester UK

Radboud University Medical Centre Nijmegen The Netherlands

Sahlgrenska University Hospital Gothenburg Sweden

University Hospital Establishment 1st November Oran Algeria

University Medical Centre Ljubljana Slovenia

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