UNLABELLED: Therapeutic apheresis (TA) is prescribed to patients that suffer from a severe progressive disease that is not sufficiently treated by conventional medications. A way to gain more knowledge about this treatment is usually by the local analysis of data. However, the use of large quality assessment registries enables analyses of even rare findings. Here, we report some of the recent data from the World Apheresis Association (WAA) registry. Data from >104,000 procedures were documented, and TA was performed on >15,000 patients. The main indication for TA was the collection of autologous stem cells (45% of patients) as part of therapy for therapy. Collection of stem cells from donors for allogeneic transplantation was performed in 11% of patients. Patients with indications such as neurological diseases underwent plasma exchange (28%). Extracorporeal photochemotherapy, lipid apheresis, and antibody removal were other indications. Side effects recorded in the registry have decreased significantly over the years, with approximately only 10/10,000 procedures being interrupted for medical reasons. CONCLUSION: Collection of data from TA procedures within a multinational and multicenter concept facilitates the improvement of treatment by enabling the analysis of and feedback on indications, procedures, effects, and side effects.

Apheresis Center North Rostock Germany

Apheresis Center University Hospital Lund Sweden

Apheresis Center University Hospital Orebro Sweden

Apheresis Unit Coimbra University Hospital Coimbra Portugal

Apheresis Unit Haematological AKH Vienna Austria

Apheresis Unit Renal AKH Vienna Austria

Apheresis Unit University Hospital Ostrava Czechia

Banc de Sang i Teixits Hospital Bellvitge Barcelona Spain

Blood Center Livorno Italy

Blood Center University Uppsala Sweden Uppsala Sweden

Bone Marrow Transplant and Apheresis Concord New South Wales Australia

Center for Immunology and Transfusion Akers University Hospital Loerenskog Norway

Clinical Immunology and Transfusion Medicine Linköping University Linköping Sweden

Department Haematology University Hospital Ankara Turkey

Department of Hematology AZ Delta Roeselare Belgium

Department of Nephrology Karlstad Sweden

Department of Nephrology Skaraborg Hospital Skövde Sweden

Department of Nephrology University Hospital Ghent Belgium

Department of Nephrology University Hospital Huddinge Sweden

Department of Nephrology University Hospital Skopje North Macedonia

Department of Nephrology University Hospital Uppsala Sweden

Hemapheretic Center of the 3rd Department of Medicine Medical Faculty and University Hospital Hradec Kralove Czechia

Institute for Endocrinology University Hospital Belgrade Serbia

Institute of Hematology and Blood Transfusion Prague Czechia

Italian National Blood Centre National Institute of Health Rome Italy

Nephrology Rheumatology Blood Purification Academic Teaching Hospital Braunschweig Germany

Public Health and Clinical Medicine Umeå University Umeå Sweden

Sanquin Blood Supply Amsterdam The Netherlands

South African National Blood Service Johannesburg South Africa

St Anna Pediatric Department Vienna Austria

Therapeutic Apheresis Unit University Hospital Vilnius Lithuania

Transfusion Medicine and Transplantation Biology University Zagreb Croatia

Transfusion Medicine Frydek Mistek Czechia

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