Gallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Review
PubMed
34571052
DOI
10.1016/j.fct.2021.112576
PII: S0278-6915(21)00609-8
Knihovny.cz E-resources
- Keywords
- Apoptosis, Cancer treatment, Gallic acid, Medicinal herbs, Metastasis, Nano-scale delivery,
- MeSH
- Apoptosis drug effects MeSH
- Antineoplastic Agents, Phytogenic administration & dosage therapeutic use MeSH
- Gallic Acid administration & dosage therapeutic use MeSH
- Humans MeSH
- Neoplasms drug therapy MeSH
- Nanoparticle Drug Delivery System * administration & dosage therapeutic use MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Antineoplastic Agents, Phytogenic MeSH
- Gallic Acid MeSH
- Nanoparticle Drug Delivery System * MeSH
Cancer is the second leading cause of death worldwide. Majority of recent research efforts in the field aim to address why cancer resistance to therapy develops and how to overcome or prevent it. In line with this, novel anti-cancer compounds are desperately needed for chemoresistant cancer cells. Phytochemicals, in view of their pharmacological activities and capacity to target various molecular pathways, are of great interest in the development of therapeutics against cancer. Plant-derived-natural products have poor bioavailability which restricts their anti-tumor activity. Gallic acid (GA) is a phenolic acid exclusively found in natural sources such as gallnut, sumac, tea leaves, and oak bark. In this review, we report on the most recent research related to anti-tumor activities of GA in various cancers with a focus on its underlying molecular mechanisms and cellular pathwaysthat that lead to apoptosis and migration of cancer cells. GA down-regulates the expression of molecular pathways involved in cancer progression such as PI3K/Akt. The co-administration of GA with chemotherapeutic agents shows improvements in suppressing cancer malignancy. Various nano-vehicles such as organic- and inorganic nano-materials have been developed for targeted delivery of GA at the tumor site. Here, we suggest that nano-vehicles improve GA bioavailability and its ability for tumor suppression.
Department of Basic Medical Sciences Neyshabur University of Medical Sciences Neyshabur Iran
Department of Pharmacy Abdul Wali Khan University Mardan 23200 Pakistan
Young Researchers and Elite Club Tehran Medical Sciences Islamic Azad University Tehran Iran
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